Objective This study was to probe into the effects of glycoproteins in murine sera on tumor cell agglutination.Methods The aggregation of B16 murine melanoma cells induced by biochemically treated and untreated murine sera was quantified in vitro.Results The pronase digestion,periodate oxidation and salt out of sera extremely reduced B16 cell aggregation.In addition,the agglutination activities of both normal and benign sera were more stable to hot than one of malignant sera.Conclusion it is sugge...