【摘要】 目的：初步探讨三氧化二砷对急性早幼粒细胞白血病的耐药机制。方法：对三氧化二砷治疗的124例APL住院病人治疗效果进行观察分析。结果：初治组缓解117例，无效7例（5．65％）。本组中86例用三氧化二砷巩固维持治疗，复发23例。复发后用三氧化二砷再次诱导，缓解15例，无效7例（30．43％），其中，4例死亡，3例用DA或HA等小剂量化疗后又获CR。结论：三氧化二砷耐药机制复杂，既存在内在性耐药，又存在获得性耐药，且与全反式维甲酸等药物无交叉耐药，耐药与剂量呈负相关，部分为可逆性的原药耐药。更多还原

【Abstract】 Objective: To discuss mechanism about drug resistance to As2O3 in APL beatment. Methods:The curative effects of 124 hospitalized patients were observed and analyzed. Results: There were 117 cases remission and 7 no effect in incipient group.86 cases were maintained treatment with As2O3 and 23 cases relapsed among them. 15 got remission,7 had no effect and 4 died after relapsed.3 patients got CR in treatment with DA or HA. Conlusion:The mechanism of drug resistance to As2O3 was very complex. There were instrisic and acquired drug resistance and no multidrug resistance in treatment APL with As2O3. There was negative correlation between dose and drug resistance. The partial drug reseistance may be reversible.更多还原