【摘要】 为探讨铅对儿童神经系统的影响，本研究在国内首次用齿铅作为儿童体内铅负荷指标，以韦克斯勒学龄前儿童智力量表（ＷＰＰＳＩ－Ｒ）修订版测得的智商（ＩＱ）作为智力发育效应指标，研究了学龄前儿童齿铅与智商的关系，并对可能影响智商的其它混杂因素进行问卷调查。结果表明：简单相关分析时，发现齿铅（２．００～１７．２１μｇ／ｋｇ）与分测验中的迷津、算术、木块图案、总ＩＱ和语言ＩＱ存在显著负相关（Ｐ＜０．０５）；而与操作ＩＱ、常识等其他项的相关则无显著性（Ｐ＞０．０５）。多因素分析时，发现引入母亲文化程度、父亲文化程度、父亲职业、母亲生育年龄和父母关心程度等混杂因素后，铅的这种负作用即减弱至无显著性（Ｐ＞０．０５）更多还原

【Abstract】 To research the effects of lead on the nervous system,tooth lead (PbT) was selected as the indicator of the lead expsoure and the intelligence quotient(IQ) tested by Wechesler Preschool and Primary Scale of Intelligence (WPPSI) was selected as the marker of the children’s intelligence.The relation of PbT and IQ was studied and others confounding factors of the children’s IQ were also acquired from the questionnaires of their parents.The results showed:by the bivariate correlation analysis,PbT was significaltly related to the sub tests,such as maze,arithmatic,stock disigen,total IQ and verbal IQ ( P<0 05 ),but not to the performance IQ and other sub tests ( P>0 05 ).By the multi factors analysis,the negative effect of the lead weakened to no significance after the Following variates,such as parents’ education,father’s occupation,the age of mother’s birth giving and the parents’ careness to their children,entered the equation ( P>0 05 )更多还原