【摘要】 为探讨低浓度一氧化碳对成年及老龄大鼠谷胱甘肽过氧化物酶（ Ｇ Ｓ Ｈ Ｐｘ）的影响。实验选用 Ｗｉｓｔａｒ雄性健康３ 月龄成年及１８ 月龄老龄大鼠。成年鼠组暴露于自然空气、１０、２５ ｍ ｇ／ｍ ３ Ｃ Ｏ，老龄鼠组暴露于自然空气、１０ ｍ ｇ／ｍ ３ Ｃ Ｏ。每组均为５ 只。暴露方式为静式染毒，２ 小时／天，染毒３０ 天。测定全血、心组织、脑组织 Ｇ Ｓ Ｈ Ｐｘ。结果表明，成年大鼠在２５ ｍ ｇ／ｍ ３ Ｃ Ｏ染毒下，第３０ 天血液及脑组织 Ｇ Ｓ Ｈ Ｐｘ 明显升高，而１０ ｍ ｇ／ｍ ３ Ｃ Ｏ染毒时，老龄大鼠及成年大鼠 Ｇ Ｓ Ｈ Ｐｘ 均未见异常变化，提示２５ ｍ ｇ／ｍ ３ 是成年鼠 Ｃ Ｏ的阈浓度，１０ ｍ ｇ／ｍ ３ 是成年鼠 Ｃ Ｏ的阈下浓度。同时还说明，在１０ ｍ ｇ／ｍ ３ Ｃ Ｏ引起 Ｇ Ｓ Ｈ Ｐｘ 升高方面，老龄大鼠并不比成年大鼠更敏感。更多还原

【Abstract】 To explore the effects of low level carbon monoxide(CO)on glutathione peroxidase (GSH P x ) in rats,the healthy 3 month old Wistar male adult rats and 18 month old Wistar male aged rats were selected as experimental animals,which were exposed to 0,10,25 mg/m 3 CO and 0,10 mg/ 3 CO respectively There were 5 rats in every group.All of the observed rats were exposed to CO statically for 30 days,2 hoursperday The activities of GSH P x in blood,heart and brain tissue of rats were determined The results showed that the activities of GSH P x in the blood and brain tissue in adult rats significantly increased at the 30th exposure day to 25 mg/m 3 CO,but those in the blood,heart and brain tissue revealed no significant variances in both of adult rats and aged rats exposed to 10 mg/m 3 CO It indicated that CO levels of 25mg/m 3 and 10 mg/m 3 for adult rats were the threshold and sub threshotd concentration respectively It was also considered that aged rats exposed to 10 mg/m 3 CO were not more sensitive than adult rats in the increase of GSH P x activities induced by CO更多还原