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¹⁸⁸Re—HEDP的制备研究

A study on preparation of ¹⁸⁸Re-HEDP

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【Author】 YIN Duanzhi; GUO Zili; ZHANG Jiong; MIN Xiaofeng; YU Junfeng; LI Busen HU Weiqing; HE Weiyu; WANG Yongxian (Shanghai Institute of Nuclear Research, the Chinese Academy of Sciences, Shanghai 201800)

【机构】中国科学院上海原子核研究所!上海； 201800；中国科学院上海原子核研究所!上海201800!上海科兴药业公司；上海；上海科兴药业公司!上海； 201800!上海科兴药业公司；中国科学院上?；

【摘要】为了研制一种新型的骨转移疼痛缓解治疗剂－(188)Re－HEDP，合成了配体HEDP，产率大于90％，并用自制(188)W－(188)Re发生器产生的(188)Re标记HEDP。系统地研究了HEDP、SnCl2和VitC的量，溶液pH值，反应温度和反应时间对标记产额的影响。标记物经HPLC和PC检测，放化纯度及标记率大于95％。在体外12h稳定。更多还原

【Abstract】 The development of a new potential bone pain palliation agent, 188Re--HEDP,was described here. The ligand HEDP was synthesized giving a yield over 90% and the is8Re--HEDP was prepared with generator--produced 188Re. Labelling yield and radiochemical purity were determined by TLC and HPLC. The optimal labelling conditions were systematically investigated and the kit formulation was developed.The labelling efficiency of 188Re--HEDP was greater than 95%, and the radiochemicalpurity was still over 90% after stored at 15℃ for 12 hrs.更多还原