【摘要】 目的 探讨糖尿病患者各期肾血流量与血浆内皮素(ET)和降钙素基因相关肽(CGRP)的关系.方法 测定54例非胰岛素依赖性糖尿病(NIDDM)患者有效肾血浆流量(ERPF)、ET及CGRP值,并与28例正常对照组进行比较.结果ET水平在DMI组、DMⅡ组和DMⅢ组均显著高于正常对照组(DMI组P<O.05、DMIⅡ组和DMⅢ组P<O.01).3组ET水平与ERPF呈负相关(P<0.01),与尿白蛋白排泄率(UAER)呈正相关(P<0.05).3组CGRP水平均低于正常对照组(P均<0.01),但3组之间CGRP水平无显著性差异(P>0.05),且与ERPF及UAER无相关关系(P>0.05).结论 CGRP对糖尿病肾病患者肾血流量的影响不如ET显著.更多还原

【Abstract】 Objective To search for the relationship between ERPF and ET\ CGRP in various phases of diabetes. Methods According to the UAER, 54 patients with NIDDM were divided into 3 groups and 28 normal persons were compared as control group. The value of ERPF was measured with I31-DIH and the level of plasma ET and CGRP were detected by RIA. Results Among 3 groups of patients, the average value of ET was superior to that of the control group (P1<0. 05,P2,3<0. 01), but the relation between ET and ERPF was a negative correlation (P<0. 01) and , conversely, ET and UAER shown a positive correlation (P<0. 05). The mean CGRP value of every group of patients was lower than that of the control group (P<0. 01). No significant dif-ferance among 3 groups of patients was observed (P>0. 05). Neither was CGRP related to ERPF nor UAER. Conclusion The influence of CGRP to ERPF in patients with diabetic nephrosis is not significant as ET does.更多还原