节点文献
抗癌药VP16-213合成工艺的改进
Improved Process for the Synthesis of Etoposide(VP16\|213)
【摘要】 鬼臼脂素经脱甲基化、酰化、缩合、脱酰制得抗癌药足叶乙甙( V P16213),总产率 172% ,较老工艺有明显的改进。
【Abstract】 Etoposide(VP16\|213),cytostatic agent useful for cancer therapy,was synthesized from podophyllotoxin via demethylation,acylation ,condensation and deacylation in total yield of 17.2%.This process is superior to the old method.
- 【文献出处】 淮海工学院学报(自然科学版) ,JOURNAL OF HUAIHAI INSTITUTE OF TECHNOLOGY , 编辑部邮箱 ,1999年03期
- 【分类号】TQ463
- 【下载频次】85