【摘要】 实验测定了小鼠血液淋巴细胞亚群及其分泌的ＴＮＦ的昼夜含量。辐射后， ＣＤ４ 和ＣＤ８ 细胞的百分含量出现完全相反的变化， 即ＣＤ４ 升高而ＣＤ８ 降低， 同时ＣＤ８ 细胞亚群正常的昼夜节律消失。ＣＤ４ 百分含量和ＣＤ４／ＣＤ８ 比值的昼夜节律性虽然存在， 但各项参数发生了改变。细胞因子ＴＮＦ的含量， 由于在个别时点的显著降低而造成整个节律的丧失。实验结果说明， 淋巴细胞亚群ＣＤ４ 和ＣＤ８ 对电离辐射的敏感性存在着差异； 除了其百分含量外， 昼夜节律的改变也可作为辐射损伤的效应指标更多还原

【Abstract】 Circadian rhythms of lymphocyte subgroups and the tumor necrotic factor(TNF)were measured in normal mice.Upon 5Gy of γ-irradiation,the level of CD4 and CD8 cells changed in opposite ways,i.e.the CD4 increased and the CD8 decreased,with the disappearance of the circadian rhythm of CD8.The CD4 and CD4/CD8 could display circadian fluctuations upon the irradiation,but all parameters of the rhythm shifted markedly.Significant reduction of the TNF level at certain timepoint of the day caused a destruction of the normal rhythm.The results suggested that a difference existed in the sensitivity to irradiation between the CD4 and CD8 subgroups,and the circadian rhythm could also be an effective indicator of irradiation damage in addition to changes of level of the lymphocyte subgroups.更多还原