【摘要】 目的:探索防治老年高血压左室肥厚(LVH)疗效好,副作用少的药物。方法:选择90例住院老年高血压LVH患者,随机分为3组,分别用ACEI、CaA、CaA加β阻滞剂治疗6个月,3组均每日测量血压、心率,并于治疗前和治疗后3、6个月做彩色超声心动图及24h动态血压检查,以观察各组药物对血压、心率、LVH和左室功能的影响。结果:13组药物均有明显降血压作用,与治疗前后对比,P均<0.01;2治疗后CaA组心率略偏快,但无统计学意义;而CaA加β阻滞剂组治疗后心率比治疗前减慢(P<0.05);3治疗6个月后IVST,PWT,LVMI减少明显(P<0.01),ACEI和CaA加β阻滞剂相似,无统计学意义,两组优于CaA组(P均<0.05);4E/A比值3组均有明显提高(P<0.05)。结论:提示3组药物均能降低血压,逆转LVH,改善心功能,但ACEI和CaA加β阻滞剂组优于单纯CaA组更多还原

【Abstract】 Objective:To find a good treatment with medicine with little side effect for the Hypertension and Left Ventricular hypertrophy (LVH) in the Elderly.Methods:We shoose 90 cases of patient who have the Hypertension LVH in the Elderly in hospitol We divide them into 3 groups with different medicine treatment.for 6 months,we use ACEI in first group,CaA in second group,CaA with β blocker in another,To observe the effect of blood pressure,heart rate,LVH and left heart function in each group,all groups are measured blood pressure,hearate,every day,the echocardiography and the Ambulatory blood pressure Monitoring (ABPM)were examined,before and after 3,6 months.Results:①after treatment HR Bp significantly decreased in all group (P<0 01);② HR were little faster in CaA,but there was no significance in statistics,and the HR were slowed down in CaA with β blocker (P<0 05);③six months after treatment,IVST,PWT,LVMI Significantly decreased (P<0 01),the effects of ACEI and CaA with β blocker were same (P>0 05),but the effects better than CaA (P<0 05);④ peak velocity E/A ratio were significantly improed (P<0 01).Conclusion:Every group medicine,could be useful medicine in the treatment of antihypertension,reversion of left ventricular hypertrophy,and improvement of heart function,but the effects of ACEI and CaA with β blocker were better than CaA更多还原