【摘要】 收集１９ 例急性期慢性阻塞性肺疾病（ Ｃ Ｏ Ｐ Ｄ）患者，６ 例 Ｃ Ｏ Ｐ Ｄ缓解期患者以及１０ 例正常对照者的痰液，以酶联免疫吸附法 （ Ｅ Ｌ Ｉ Ｓ Ａ） 测定其痰液白细胞介素 １６ （ Ｉ Ｌ１６） 水平， 以探讨 Ｉ Ｌ１６ 在 Ｃ Ｏ Ｐ Ｄ发病机制中的作用及其对 Ｃ Ｏ Ｐ Ｄ气道炎症的临床意义。结果， Ｃ Ｏ Ｐ Ｄ 患者急性发作期痰 Ｉ Ｌ１６ 水平（１ ２３３±４９２４４ ｎｇ／ Ｌ） 和缓解期 （１ ２３２±５１３５３ ｎｇ／ Ｌ） 均明显高于正常对照者 （６６０７７±３１２１１ ｎｇ／ Ｌ） （ Ｐ＜ ００５ ）。此外， Ｃ Ｏ Ｐ Ｄ患者痰液 Ｉ Ｌ１６ 水平与 Ｆ Ｅ Ｖｌ呈负相关（ｒ＝ － ０．４３， Ｐ＜ ００５ ）。以上结果表明， Ｉ Ｌ１６ 参与了 Ｃ Ｏ Ｐ Ｄ气道炎症的发病过程， 其机制可能与激活 Ｔ 淋巴细跑有关。更多还原

【Abstract】 In order to explore the role of interleukin16(IL 16) in the pathogenesis of chronic obstructive pulmonary disease(COPD), and to evaluate the clinical values of IL 16 in the airway inflammation of COPD, IL 16 levels of induced sputum from 19 patients with acute COPD, 6 patients with stable COPD and 10 normal subjects were detected by ELISA method. The results showed that IL 16 levels of induced sputum in patients with acute COPD (1 233±492 44 ng/L) and with stable COPD(1 232±513 53 ng/L) were much higher than that in normal subjects(660 77±312 11 ng/L)(P<0 05). In addition, there was a negative correlation between IL 16 of induced sputum and FEV1 (r=-0 43,P<0 05).Our findings indicate that IL 16 could be involved in the airway inflammation process of COPD by activating T lymphocytes.更多还原