【摘要】 制作和研究了病家雏鸡铝氟联合中毒模型，用100日龄雄性种鸡84只随机分为7组，病区玉米及毒物加入饲料自由进食。实验期3个月。结果表明，各实验组均有2－5只典型骨软化的鸡，并都出现小细胞性盆血。饲氟170×10－6－300×10－6的4个组骨氟增高十多倍，骨铝也均增高数倍。高氟铝组骨氛是NaF组的88％，骨铝是54％。何铝329×10-6与686×10-6的两个组骨铝仅为对照组的79%（P＜0.2）与64%（P＜0．01）。骨铝与饲铝r=-0．58（P＜0.2），与铜氟r＝0．88（P＜0．01），与骨氟r＝0．96％（P＜0．001）。各实验组肝、肾铝含量增高。骨计量检测务实验组均有骨形成率下降、骨质疏松、软化的铝骨病病理改变。3个加氟组骨矿沉积率、细胞水平骨形成率等已高于对照组，病区玉米和丙纶铝组则均低于对照组，出现明显分异。表明铝降低氟蓄积的同时，氮和促进了铝的吸收和蓄积，但高氛更显著地降低了高铝的蓄积率。在性成熟后，高氟组和高氟铝组骨软化与骨硬化可在不同层位共存。铝氟联合中毒在性成熟前以铝危害为主。摄铝过量不一定有骨铝蓄积，但可出现铝骨病及其它铝危害表现。更多还原

【Abstract】 Al-F toxicosis cocks were found in fandlies of patients with the same disease. The idea of es-tablishing cock model of this disease was raised and catried out. 84 cocks aged 100 d were randomly di-vided into 7 groups and fed with thexture of com and toxicant for 3 months. The results showed that 2 ~ 5typical osteomalacia cocks occurred in each treated group (TF) and all of the cocks had microryticaneamia. Bone F content of cocks in 4 groups by which an amount of 170×10-6 ~ 300-×10-6 of F trastaken increased by more than ten times and bone Al content by several times. The ratio of bone F and Alof high F - Al groups to those of NaF groups were 88% and 54% respectively. The bone Al content 0f 2groups of which the amount of Al in food 329×10 - 6 and 686×10 -6 were 79 % and 64 % of that of control respectively. The correlation coefficients r of bone Al and food Al, bone A-l and food F, and bone Al andbone F were - 0.58, 0. 88 and 0.96 respectively. In TF groups, liver Al and kidney Al increased, 0s-teogenesis rate decreased, and pathological changes such as osteoporosis and osteomalacia occurred. In the3 groups of which the food was added F, the rat of mine depositing and osteogenesis in cell level were higher than that of control groups, but those of cocks fed with corn from disease areas and 2 high Al groupswere lower than controls which suggested that Al reduced the accumulation rate of F while F promoted theabsorption and accumulation of Al. But high F would reduce the accumulation rate of high Al markedly.Afer sexual maturation the osteomalcia in high - Al - F groups might changed into osteopetrosis. Beforesexual moturation, Al - F toxicosis hanly expressed as jeopardizing by aluminium. Al didn’t necessarily,accumulate in bone when excessive Al was taken in, but harm caused by Al might present.更多还原