【摘要】 以环氧氯丙烷对琼脂凝胶珠进行活化反应后键联热聚ＩｇＧ，制成一种新型类风湿关节炎免疫吸附剂。确定了最佳制备条件，使凝胶上环氧基的含量达１１０μｍｏｌ／ｇ，对热聚ＩｇＧ的固定量达６ｍｇ／ｇ。在体外条件下吸附剂对三种类风湿因子ＩｇＭＲＦ，ＩｇＧＲＦ及ＩｇＡＲＦ的吸附量分别达３４００、２２５０和２４００ＩＵ／ｇ，具有良好的应用前景更多还原

【Abstract】 Epoxy-activated agar gel beads were prepared, then used as a carrier to couple heat-aggregated IgG. Thus a new immunoadsorbent for rheumatoid arthritis was developed. Under the optimal preparing conditions the content of epoxy groups incorporated onto agar gel was 110 mol/g and 6 mg/g heat-aggregated IgG was immobilized. At last, the removal capacity of the adsorbent to rheumatoid factors was investigated by in vitro adsorption tests, and the removal amount of IgMRF, IgGRF and IgARF was 3400, 2250 and 2400 IU/g, respectively.更多还原