【摘要】 目的　探讨尼可地尔停跳心脏的效果。方法　选成年健康雄性杂种犬５ 例，建立体外循环模型。阻断升主动脉，主动脉根部灌注２００ μｍｏｌ／Ｌ温血尼可地尔（Ⅰ组）５００ ｍＬ，观察心脏停跳情况。３０ ｍｉｎ 后开放，观察心脏复跳情况。复跳３０ ｍｉｎ 再阻断升主动脉，灌注１００ μｍｏｌ／Ｌ温血尼可地尔（ Ⅱ组） ，其他同Ⅰ组。第２ 次复跳３０ ｍｉｎ 后第３ 次阻断，造成单纯全心缺血，观察心跳情况。结果　两组浓度的药物均可使犬心停跳，再灌注后可复跳；单纯全心缺血３０ ｍｉｎ 未见停跳。结论　２００ μｍｏｌ／Ｌ和１００ μｍｏｌ／Ｌ的尼可地尔均可使犬心停跳，再灌注后可复跳。更多还原

【Abstract】 Objective To evaluate the cardioplegic effect of nicorandil.Methods Cardiopulmonary bypass model was established in five adult male hybrid dogs. After clamping aorta ascendens, 500 mL of nicorandil with the concentration of 200 μmol/L in warm blood was perfused to the root of aorta (group Ⅰ) and the process of cardiac arrest was observed. After 30 minutes of ischemia, the clamp was removed, and the process of cardiac resuscitation was observed. After 30 minutes of resuscitation, the aorta ascendens was clamped again, nicorandil with the concentration of 100 μmol/L in warm blood was perfused to the root of aorta (group Ⅱ), and other factors were controlled the same as group Ⅰ. After 30 minutes of second resuscitation, the aorta was clamped and no perfusate was given, to creat a pure heart ischemia model and the heart beat was monitored.Results Both nicorandil concentration could arrest dog’s heart, which could be resuscitated after reperfusion; Pure ischemia without perfusion could not creat cardiac arrest. Conclusion Both 200 μmol/L and 100 μmol/L of nicorandil can arrest the dog’s heart, which can be resuscitated by reperfusion.更多还原