【摘要】 目的　探讨心肌抗体 (HRA)结合链球菌膜抗原吸附试验对心血管疾病的诊断意义。方法　应用酶免疫斑点法检测 117例各种心脏疾病患者和 3 2例正常人血清的HRA ,并将测得的阳性血清用A组链球菌膜抗原进行吸附试验。结果　风心病、原发性心肌病、病毒性心肌炎、缺血性心脏病和其他心脏病患者HRA阳性率的分别为 65 7%、5 7 9%、5 0 %、2 6 7%和 2 5 % ,吸附试验阳性率则分别为 73 9%、18 2 %、11 1%、0 %和 0 %。吸附后风心病的阳性率明显高于原发性心肌病或病毒性心肌炎 (P <0 0 1)。结论　应用酶免疫斑点法检测HRA结合链球菌膜抗原吸附试验 ,既可提高风心病诊断的特异性 ,也有利于各种心脏病的鉴别更多还原

【Abstract】 Objective To evaluate the significance of heart reactive antibodies (HRA) combined with absorption assay in the diagnosis of heart diseases. Methods 117 patients with a variety of heart diseases and 32 health individuals were tested by the IELISA-HRA assay. HRA absorption assay was also carried out by applying with streptococcal A cell membrane antigen on 55 patients with positive HRA sera. Results The positive rate of HRA was 65 7% in rheumatic heart disease, 57 9% in primary myocardiopathy, 50% in viral myocarditis, 26 7% in ischemic heart disease, 25% in other heart diseases. With HRA absorption assay, it was 73 9%, 18 2%, 11 1%, 0%, 0%, respectively. The positive rate of HRA absorption assay was significantly higher in rheumatic heart disease than that in primary myocardiopathy or viral myocarditis ( P <0 01). Conclusion The IELISA-HRA assay combined with absorption assay will be significant for the differenciation of heart diseases and gives a specific means for the diagnosis of rheumatic heart disease.更多还原