【摘要】 动态测定76例临床明确诊断的急性心肌梗塞患者和15例正常对照组肿瘤坏死因子和血浆神经肽Y的水平。结果显示,正常对照组NPY为93.3±10.6ng/L,急性心肌梗塞组在发病后1天NPY异常升高,为160.2±26.3ng/L,发病后第7天为121.3±24.7ng/L,均高于正常对照组(p<0.05);与NPY不同,正常对照组的TNF为0.97±0.38μg/L,在急性心肌梗塞发病后第1天升高至2.48±0.89μg/L(p<0.01),但发病后第3天降至1.12±0.37μg/L,已接近正常(p>0.05)。提示,TNF在急性心肌梗塞的发生中有重要作用,但与患者预后无直接关系;而血浆神经肽Y的水平不仅与急性心肌梗塞患者的发生有关,而且在急性心肌梗塞的病程和预后中有重要价值。更多还原

【Abstract】 Serum tumor necrosis factor(TNF) and plasma neuropeptide Y(NPY) levels were dynamically measured in 76 patients with acute myocardial infarction (AMI) and 15 normal controls. The results showed that mean plasma NPY level was 93.3 + 10.6ng/L in normals. However, there was abnormal increase (160.2 + 26.3ng/L) in patients at first day fater AMI event and it was decreased to 121.3 + 24.7ng/L of 7th day after AMI, which was still significantly higher than that in controls. The serum level of TNF was 0.97 + 0.38μg/L in normal group and reached peak value (2.48 + 0.89)μg/L at first day after AMI (p<0.01). However, it was nearly normal (1.12 + 0.37μg/L) at third day after AMI(p>0. 05). These suggested that TNF might have an important role in the development of AMI but have no relation with the prognosis, NPY was not only related to the occurrence of AMI but also played important roles in the disease course and was of prognostic value.更多还原