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LMP2与LMP7基因多态性与强直性脊柱炎并发虹睫炎易感性关系的研究
Association of the polymorphism of LMP2 and LMP7 genes with the susceptibility to acute anterior uveitis in patients with ankylosing spondylitis
【摘要】 目的研究LMP基因多态性与强直性脊柱炎并发虹睫炎发病的关系。方法应用PCR对正常人和病人进行HLAB27检测以及LMP2和LMP7扩增。CfoI进行限制性酶切图谱分析。结果强直性脊柱炎有虹睫炎(AS+AAU)病史以及单纯虹睫炎(AAU)患者LMP2基因BB纯合型较正常人以及强直性脊柱炎(AS)患者明显增高(P<005),AS+AAU患者BB型OR=36,AAU患者BB型OR=583。LMP7基因多态性无明显差别。结论在我国汉人中,LMP2基因多态性与AS+AAU以及AAU发病存在明显相关关系。
【Abstract】 Objective To evaluate the polymorphism of LMP2 and LMP7 genes in patients with ankylosing spondylitis (AS) and /or acute anterior uveitis (AAU). Methods HLAB27 typing was performed and LMP2 and LMP7 amplified fragment length polymorphisms were determined after PCR and digestion with CfoI restriction enzyme. Results There was a significantly increased LMP2BB genotypic frequency in patients with AS+AAU (857%) and AAU (87%) when compared with controls (533%) and AS patients (625%) (P<005),but no difference in LMP7 genotype.Odds ratio (OR) relating LMP2 BB and AAU was 583 and OR for AS+AAU was 36. Conclusion The polymorphism of LMP2 gene is strongly associated with the development of AAU in AS patients and uncomplicated AAU patients.
【Key words】 LMP genepolymorphismspondylitis; ankylosingiridocyclitis;
- 【文献出处】 中华风湿病学杂志 ,CHINESE JOURNAL OF RHEUMATOLOGY , 编辑部邮箱 ,1999年02期
- 【分类号】R593.23
- 【被引频次】10
- 【下载频次】135