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小剂量甲氨蝶呤对RA患者血浆TNFαIL-6水平影响的研究

Influence of small dose methotrexate upon plasma TNFα and IL 6 levels of patients with rheumatoid arthritis

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【作者】 傅建斌任天丽郭素娟范会萍李武威任丽群

【Author】 FU Jianbin,REN Tianli,GUO Sujuan,et al.Affiliated Hospital,Luoyang Medical College,Luoyang 471003

【机构】 洛阳医学高等专科学校附属医院铁道部第15工程局医院

【摘要】 目的 探讨小剂量甲氨蝶呤( M T X) 对 R A 患者血浆 T N Fα、 I L6 水平的影响。方法 用放射免疫分析( R I A) 法研究了30 例 R A 患者 M T X(10 mg/ W) 治疗前后血浆 T N Fα、 I L6 水平的变化。结果  M T X 治疗6 周后血浆 T N Fα、 I L6 水平明显降低,以后进一步降低( P< 001) 。结论  M T X 能有效地降低 R A 患者血浆 T N Fα、 I L6 水平,诱导病情缓解

【Abstract】 Objective To probe the influence of small dose methotrexate (MTX) upon plasma TNFα and IL 6 levels of patients with rheumatoid arthritis (RA).Methods The plasma TNFα and IL 6 level changes were studied by radioimmunologic assay (RIA) in 30 patients with RA before and after treatment of MTX (10 mg/w).Results After 6 weeks when they were treated with MTX,their plasma TNFα and IL 6 level reduced notably,and then continously reduced ( P <0 01).Conclusion Small dose MTX can reduce plsma TNFα and IL 6 levels of the patients with RA,and make their conditions improve.