【摘要】 目的 :建立青藤碱的透皮吸收研究方法 ,比较青藤碱渗透小鼠皮肤、裸鼠皮肤、家兔皮肤、大鼠皮肤、猪耳皮肤及人体皮肤的透皮吸收行为。方法 :青藤碱的含量测定采用HPLC法 ,计算透皮速率常数J,比较青藤碱渗透上述 6种实验皮肤的透皮速率常数。结果 :青藤碱透过 6种皮肤的透皮速率常数分别为 46 6 7± 16 35、40 34± 8 40、17 6 0± 9 46、2 3 71± 8 79、44 5 6± 11 2 7、38 33± 13 81。结论 :青藤碱对 6种皮肤的渗透性 ,以裸鼠及猪耳皮肤的透皮速率常数与人体皮肤较为接近。更多还原

【Abstract】 Objectives:(1)To establish methods for study on transdermal study of sinomenine, (2)To study comparatively on the transdermal profile of sinomenine var six kinds of animal skin Methods: HPLC method is used for the determination of sinomenine; Improved Franz cell is used for the transdermal study, and the transdermal speed constants of sinomenine var six kinds of animal skin are compared Results: the transdermal speed constants of sinomenine var skin of mice, hairless mice, rabbit, rat, pig ear, person are 46 67±16 35、40 34±8 40、17 60±9 46、23 71±8 79、44 56±11 27、38 33±13 81 respectively Conclusion: the transdermal profiles of sinomenine var skin of hairless mice and pig ear are more similar to that of person skin更多还原