【摘要】 为探讨层粘蛋白 ( L N)在大肠癌发病过程中的临床意义 ,本文应用放射免疫法 ( RIA)测定 2 3例有转移的大肠癌患者 ,2 0例无转移的大肠癌患者及 2 0例健康献血员血清中 L N水平。结果显示 ,大肠癌患者血清中 L N含量(μg/ L )为 2 0 3± 3 3 ,显者高于健康对照组 10 6± 2 0 .8( P<0 .0 1)。已转移的大肠癌患者血清的 L N含量为 2 5 6± 12 .8,明显高于未转移的大肠癌患者血清中该蛋白含量 15 4± 2 0 .2 ( P<0 .0 1)。我们认为 ,血清中层粘蛋白的测定可作为大肠癌早期诊断的手段之一 ,并且动态观察血清 L N的水平变化是判断大肠癌转移的一个简便有用的指标。更多还原

【Abstract】 To understand the clinical significance of serum laminin(LN)in the disease course of colorectal cancer,we detected serum level of LN in 23 patients with metastasis of colorectal cancer,in 20 patients with non metastasis.of colorectal cancer and in 20 normal controls.The method we used for this study was radioimmunoassay(RIA).Our results showed that serum level of LN(μg/L)in patients with colorectal cancer was significantly higher than that in normal controls(203±33 vs 106±20 8,P<0 01).Besides,serum level of LN in patients with metastasis of colorectal cancer was significantly higher than that in patients with non metastasis of colorectal cancer(256±12 8 vs 154±20 2,P<0 01).We concluded that detection of serum level of LN may be one of the melthods of early diagnosis for colorectal cancer,and that successive detection of serum level of LN could be a simple and useful test for predicting the metastasis of colorectal cancer.更多还原