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口腔癌患者血中自由基的变化

Changes of Free Radical in the Blood of Patients with Oral Carcinoma

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【作者】 黄晓红郑辉施斌黄伟明陈乃俊林李嵩

【Author】 Huang Xiaohong\+1, Zheng Hui\+2, Shi Bin\+1, et al (1 Department of Stomatology, The Affiliated First Hospital, Fujian Medical University, Fuzhou, 350005 (2 Department of Biochemistry, Fujian Medical University, Fuzhou, 350004)

【机构】 福建医科大学附属第一医院口腔科!福州350005福建医科大学生物化学教研室

【摘要】 目的 探讨口腔癌患者血中自由基在术前、术后的变化 ,探讨自由基与口腔癌的关系。 方法 测定 2 5例口腔癌患者术前及术后 7天血中自由基的有关项目 ,并与 30例正常人组比较。 结果 口腔癌组脂质过氧化物 ( L PO)高于对照组 ,超氧化物歧化酶 ( SOD)、一氧化氮 ( NO)低于对照组 ,差异均有高度显著性 ( P<0 .0 1) ;口腔癌患者术后 7天测定 L PO、SOD与术前比较差异无显著性 ( P>0 .0 5 ) ,NO浓度低于术前 ( P<0 .0 5 )。 结论 口腔癌与体内自由基密切相关。

【Abstract】 To study preoperative and postoperative change of free radical change in the blood of patients with oral carcinoma and make a comparison with a normal group to explore the relationship between free radical and oral carcinoma \ Methods\ Determine the relevant items of free radical in the blood before operation and 7 days after operation and make a study in a control group of 30 normal cases \ Results\ Lipid preoxide(LPO) in oral carcinoma group was higher than that in the normal control group, and superoxide dismutase(SOD) and nitric oxide(NO) were lower than those in normal control group,all with significant difference(P<0 01) \ In oral carcinoma patients,the measurements of LPO and SOD 7 days after operation showed no significant difference(P>0 05), compared with preoperation \ The concentration was lower than that before operation(P<0 05) with significant difference \ Conclusion\ There is a close association between oral carcinoma and free radical in the body \;

  • 【文献出处】 福建医科大学学报 ,JOURNAL OF FUJIAN MEDICAL UNIVERSITY , 编辑部邮箱 ,1999年03期
  • 【分类号】R739.8
  • 【下载频次】31
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