【摘要】 方法:观察用爱维治治疗急性心肌梗死前后血浆内皮素（ET）、血栓素A₂（TXA₂）、前列腺素（PGI₂）、血浆肾素（PRA）及血管紧张素Ⅱ（AngⅡ）等指标的变化。将75例急性心肌梗死病人随机分为3组;爱维治治疗组（AVn=24）、对照组（COn=21）和溶栓组（尿激酶,链激酶n=30）。AV组给予爱维治30nk+5％葡萄糖250ml静点,每日1次,共10天。结果:AV组使TXA₂降低,PGI₂升高,并使PRA和AngⅡ下降。TXA₂水平AV组要比CO组和溶栓组低,其PGI₂水平则高于其他二组,三组的ET水平均有下降,但组间无明显差异。AV组和CO组的PRA、AngⅡ水平在治疗后有所下降,而溶栓组升高。结论:爱维治抗血栓作用与其抑制血小板激活作用有关。更多还原

【Abstract】 To investigate the effects of Actovegin on myocardial ischemia.Methods: TXA2,PGI2,ET,PRA and AngⅡ were obtained from patients with acute myocardial infarction.75 cases a-cute myocardial infarction(AMI) were randomized into three groups: Actovegin group(AV n=24), Control group(CO n=21) and thrombolysis therapy group (UK,SK n= 30) . Results: A marked elevation of PGI2 and a low level of TXA.2 were observed in AV group after treatment, which may show that Actovegin act on dilation of the coronary artery and against aggregation of plates. The level of TXA2 in AV group was lower than that in control group and thrombolysistherapy group, the PGI2 was higher than the other two groups ,ET decreased slightly in each group, the PRA and AngⅡ were decreased in group AV and group CO, and increased in thrombolysis therapy group. Conclusion: These results indicate that intravenous AV may be involved in antiplatelet aggregative effect.更多还原