【摘要】 目的　探讨病毒性脑炎（ 病脑）患儿脑脊液中一氧化氮（ＮＯ）、一氧化氮合酶（ＮＯＳ）、丙二醛（ＭＤＡ） 和超氧化物歧化酶（ＳＯＤ）的变化特点。方法　应用比色法对病脑患儿急性期、恢复期脑脊液中ＮＯ，ＮＯＳ，ＭＤＡ 及ＳＯＤ 进行对比分析。结果　病脑患儿脑脊液中ＮＯ（５９ ．８±１５ ．０ μｍｏｌ／Ｌ），ＮＯＳ（２．７３±０ ．５９ Ｕ／ｍｌ），ＭＤＡ（１３．２ ±２ ．２０ ｎｍｏｌ／ｍｌ） 及ＳＯＤ（２８ ．９ ±１２．９ ＮＵ／ｍｌ） 水平明显高于对照组（Ｐ＜ ０．０１）；１４ 例病儿急性期ＮＯ，ＮＯＳ，ＳＯＤ含量明显高于恢复期（Ｐ＜ ０．０１） ，ＭＲＩ检查阳性组ＮＯ 水平高于阴性组（ Ｐ＜ ０ ．０５） 。结论　ＮＯ可能参与脑水肿的形成和髓鞘的破坏过程；合理应用甘露醇及抗氧化治疗应予重视。更多还原

【Abstract】 Objective To study the change of nitric oxide (NO), nitric oxide synthetase (NOS), malondialdehyde (MDA) and superoxide dismutase (SOD) level in cerebrospinal fluid (CSF) of children with viral encephalitis.Methods CSF NO, NOS, MDA and SOD were measured using colorimetric methods and the levels were compared between acute and recovery stages in children with viral encephalits.Results CSF NO ( 59.8±15.0 μmol/L),NOS (2.73±0.59 μmol/L) and SOD (28.9±12.9 NU/ml) levels in the acute stage were higher than those observed either in the recovery stage of the patients or in the normal control children (P<0.01). MDA (13.2±2.20 nmol/ml) reduced in the recovery stage but the level still was higher than normal (P<0.01). NO and MDA levels were higher in the patients with positive MRI examination than in the patients with negative MRI (P<0.01). Conclusions NO may be involved in the formation of cerebral edema and the destruction process of myelin sheath in the viral encephalitis. Thus, appropriate mannitol and antioxidative therapy for the encephalitis has to be taken into consideration.更多还原