【摘要】 目的：观察野罂粟总生物碱中八种生物碱单体心血管应的构效关系。方法：采用离体实验观察单体对ＫＣｌ所致兔胸主动脉环收缩的影响，并以Ｖｅｒ 作对照。结果：野罂粟碱（ｎｕｄｉｃａｕｌｉｎｅ，Ⅰ）、瑞芙热米定（ｒｅｆｒａｍ ｉｄｉｎｅ，Ⅱ）、黑龙辛甲醚（ａｍ ｕｒｅｎｓｉｎｉｎｅ，Ⅳ）、黑龙辛（ａｍ ｕｒｅｎｓｉｎｅ，Ⅴ）、野罂粟醇（ａｍ ｕｒｏｌｉｎｅ，Ⅵ）和七号生物碱（Ⅶ）均可使ＫＣｌ量－ 效曲线不平行右移，最大反应压低，其ＩＣ５０分别为０．２０，０．８０，０．１６，０．６０，０．６０，０．１６ｍ ｍ ｏｌ·Ｌ－ １。结论：野罂粟碱类（Ⅱ，Ⅳ，Ⅴ，Ⅶ）对经ＰＤＣ钙内流抑制效果较强，其中以Ⅱ作用最强；原阿朴菲类（Ⅵ，ⅧＡ，Ｘ）的抑制作用较弱更多还原

【Abstract】 Objective:To study relations between the structure and effects of eight monmers of papver nudicaule alkaloids on cardiovescular.Methods:Isolated rabbit aortic rings were used to study the effects of eight monomers on their contraction induced by KCl.Results:Monomer Ⅰ,Ⅱ,Ⅵ,Ⅴ,ⅥandⅦshifted KCl dose response curves to right in unparallel fashion and decreased the maximal response.The IC 50 of them were 0.2,0.08,0.16,0.60,0.60,0.16mmol.L -1 ,respectively.Conclusion:The inhibitory effect of the isopapaver group to Ca 2+ influx through PDC is more intensive than that of proapromorphine group. Monomer Ⅱ is the most intensive of the isopapaver group.更多还原