【摘要】 睡眠有３种成分：浅睡眠、慢波睡眠（ｓｌｏｗｗａｖｅｓｌｅｅｐ，ＳＷＳ）和快眼动睡眠。提出催眠药物开发新构想，即ＳＷＳ是最重要的睡眠成分，选择性增加深睡眠的催眠药物最重要，它将对改善失眠，辅助治疗焦虑症、抑郁症和痴呆症具有重要意义。近十年研究进展包括：（１）腹外侧视前区结节乳头体可能是睡眠觉醒的中枢发生部位。基底前脑吻端ｐＧＤ２敏感性睡眠促进区参与睡眠调节；（２）生长激素释放激素、褪黑激素、ｐＧＤ２、ＩＬ１和腺苷均可增加ＳＷＳ。本系神经药理研究室关于ＳＷＳ的研究工作包括：（１）建立起家兔和大鼠睡眠成分自动分析系统（ａｕｔｏａｎａｌｙｓｉｓｓｌｅｅｐｉｎｇｓｔａｇｅｓｓｙｓｔｅｍｓ，ＡＳＳ）；（２）利用ＡＳＳ研究了免疫增强剂如转移因子、胞壁酰二肽、肿瘤坏死因子，以及５ＨＴ１Ａ受体激动剂和５ＨＴ２受体拮抗剂对睡眠成分的影响；（３）探讨５ＨＴ１Ａ受体、ＲＥＭ睡眠和５ＨＴ２受体间的关系。近十年睡眠调节的研究进展证明“构想”的可行性和正确性，并提示，在中枢可能存在免疫增强ＴＮＦ增多５ＨＴ更新率增加ＳＷＳ途径。激动５ＨＴ１Ａ自身受体与拮抗５ＨＴ２受体有类似效果，二者间有协同作用。开发选择性延长?更多还原

【Abstract】 There are three sleeping stages: light sleep, slow wave sleep (SWS)and rapid eye movement sleep(REM sleep). A hypothesis is presented: SWS is the most important one in the sleeping stages. The most important hypnotics will be the drugs selectively promoting SWS. The drugs will be improving insomnia, helping the treatment of anxiety, depression and dementia. The recent decade advances on sleep regulation include the following: (1)Ventrolateral preoptic area tuberomammillary nucleus (VLPO TMN) seems to generate sleep and wakefulness . The rostral basal forebrain, which was sensitive to pGD 2, may be involved in regulating sleep. (2)Growth hormone releasing hormone (GHRH), melatonin, prostaglandin D 2 (pGD 2), IL 1 and adenosine could increase the SWS. Our studies on SWS include the following: (1)Setup the auto analysis sleeping stages systems (ASS)for rabbits and rats. (2)With the ASS the effects of immune enhancing substances were studied such as transfer factor, muramyl dipeptide and TNF on sleeping stages in rabbits and the effects of 5 HT 1A receptor agonist and 5 HT 2 receptor antagonist on sleeping stages in rats. (3)Researched the relationship between 5 HT 1A receptor, depriving REM sleep and 5 HT 2 receptor. The recent advances on sleep regulation proved feasibility and validity of the hypothesis. Our results showed the approach: the immune enhancing TNF increasing 5 HT turnover increasing SWS. The result of stimulating 5 HT 1A receptor was similar to that of antagonizing 5 HT 2 receptor, and showedsynergistic effects with the both. The development of new type of hypnotics, which selectively prolong SWS, might consider the following clues : pGD 2 stimulators, adenosine receptor agonists, immune enhancing substances, some hormones and agents influencing 5 HT 2 subreceptors.更多还原