【摘要】 目的：探讨ｃｙｃｌｉｎＥ蛋白表达与肠型胃癌的临床病理特征及预后的关系。方法：以免疫组化法分析５９例肠型胃癌的ｃｙｃｌｉｎＥ蛋白表达情况。结果：正常胃粘膜上皮细胞呈阴性反应，而３０例（３０／５９）肠型胃癌组织被免疫染色。ｃｙｃｌｉｎＥ的异常表达与肿瘤的浸润深度显著相关，强阳性者５年生存率低。结论：ｃｙｃｌｉｎＥ的异常表达与肠型胃癌的发展有关，并可作为一项预后指标更多还原

【Abstract】 Objective: To investigate the correlation of cyclin E expression with the clinicopathologic features and prognosis of intestinal type gastric cancer. Methods: The expression of cyclin E protein in 59 patients with intestinal type gastric cancer was studied by means of immunohistochemistry. Results: Normal gastric epithelial cells were negative, while 30(30/59) carcinomatous tissues were immunostained. Abnormal expression of cyclin E was significantly related to invasion depth of intestinal type gastric cancer. The patients with strongly positive expression of cyclin E tended to have a lower postoperative 5 year survival rate than other groups. Conclusion: Abnormal expression of cyclin E might take part in and promote the progression of intestinal type gastric cancer, and it might be used as a prognostic factor.更多还原