【摘要】 目的　探讨三氧化二砷（Ａｓ２Ｏ３）与联合化疗序贯治疗急性早幼粒细胞白血病（ＡＰＬ）的疗效与副作用。方法　首先对３ 例初治病人与４例复发病人分别给予全反式维甲酸（ＡＴＲＡ）和（Ａｓ２Ｏ３ ）以诱导缓解，完全缓解（ＣＲ）后用ＤＡ、ＨＡ方案与Ａｓ２Ｏ３ 序贯治序。结果　７ 例病人均获ＣＲ，目前仍保持ＣＲ状态，持续ＣＲ的时间已１０个～４４个月。结论　Ａｓ２Ｏ３ 与联合化疗序贯治疗ＡＰＬ具有疗效好，毒副作用轻，易于长期维持治疗等优点。更多还原

【Abstract】 Objective To observe the effect and side effect of sequentially using arsenic trioxide (As 2O 3) and combination chemotherapy for the treatment of the patients with acute promyelocytic leukemia(APL).Methods 3 cases of newly diagnostic APL patients,were induced to complete remission (CR) by all tran retinoic acid (ATRA),and 4 cases of the relapse APL by As 2O 3.After CR,As 2O 3 and DA or HA regimens was used sequentially.Results A11 7 patients achieved and remained CR until now and the time of CR was 10～44 months.Conclusion The therapy of sequentially using As 2O 3and combination chemotherapy for treatment of APL has the advantages of achieving good results with mild side effects acceptable in the long period of maintenance therapy.更多还原