【摘要】 目的：探讨血清ｓ Ｉ Ｌ２ Ｒ 的表达水平与肺癌诊断、疗效判定及预后的关系。方法：用双抗体夹心法测定肺癌患者血清中 ｓ Ｉ Ｌ２ Ｒ 水平，并进行化疗前后对比。结果：肺癌患者 ｓ Ｉ Ｌ２ Ｒ 的生物活性高于正常对照组及呼吸系统良性疾病组，化疗后 ｓ Ｉ Ｌ２ Ｒ 水平较化疗前明显降低，差异显著（ Ｐ＜ ００１）。结论：ｓ Ｉ Ｌ２ Ｒ 可作为肺癌诊断、疗效判定及预后评价的辅助性指标。更多还原

【Abstract】 Objective:To study the significance of MDR1 expression in leukemia,and to extablish a fast and easy method of MDR1 expression detection.Methods:MDR1/Pgp was labeled with FITC monoclonal antibody of MDR1,and then detected by flow cytometry.Results:The expression of MDR1 in acute leukemia and chronic leukemia were 8.98±7.74 and 3.60±1.30,respectively.There was significantly difference between the two groups ( P <0 01).Among the subsets of acute non lymphocyte leukemia,MDR1 expression in M 3 was significant lower,and increased successively in M 2 and M 4.Conclusion:These findings indicated MDR1 expression could be a predictor in assessing the prognosis of leukemia.And flow cytometry is a fast and easy method in detection of MDR1 exxpression.更多还原