【摘要】 利用ＲＩＡ法测定经皮层ＥＥＧ、ＰＥＴ、ＳＰＥＣＴ、ＭＲＩ、ＣＴ等检查而定位明确的６４例癫痫患者癫痫发作前后血清皮质醇水平。结果表明，癫痫病人血清基础皮质醇水平明显低于正常人。癫痫发作后９２．２％的病人血清中皮质醇水平升高，４０．６％的病人发作后１５分钟皮质醇水平达到峰值，失神性发作后血清皮质醇水平不增加或增加不明显，而强直－阵挛性、复杂部分性发作后皮质醇水平明显升高。然而发作后血清皮质醇水平的变化与癫痫灶位置无关，不同病灶的癫痫患者癫痫发作后均可引起皮质醇水平升高。结果提示癫痫过程影响下丘脑－垂体－肾上腺（ＨＰＡ）轴的功能活动，使基础皮质醇水平减低，癫痫发作后均可引起不同病灶位置的血清皮质醇水平升高，而且发作类型影响发作后皮质醇水平的变化。更多还原

【Abstract】 Serum cortisol concentrations in 64 epileptic patients before and after seizures were determined by radioimmunoassay. The epileptic foci were determined by cortisol-EEG,PET,SPECT,MRI,CT examinations.The results indicate that basal levels of serum cortisol in all epileptic patients were lower than normal controls.After seizurse,serum cortisol levels were increased in 92.2% patients,and cortisol levels were achieved peak in 40.6% patients at 15 min postictal.Serum cortisol levels were not increased or not significantly increased in absentia seizures, but cortisol levels were significantly increased in epileptic patients with generalized tonicclonic (GTC) and complex partial (CP) seizures. However, the alternation of cortisol levels had no relation with the site of epileptic focus.Any epileptica foci could lead to a rise of serum cortisol levels. The results suggest that seizures of epilepsy had effects on function of the HPA axis.During seizures, serum cortisol levels were increased in epileptic patie更多还原