【摘要】 为观察自身免疫性甲状腺炎（ＨＤ） 腺体内淋巴细胞Ｆａｓ－ Ｌ的表达及血清ｓＡＰＯ－ １／Ｆａｓ的测定， 与ＨＤ病因及临床意义的关联。本文应用抗链霉菌抗生素蛋白－ 过氧化酶连接法（ＳＰ法）对甲状腺细胞学涂片进行淋巴细胞Ｆａｓ－ Ｌ 的表达的观察； 并应用ＥＬＩＳＡ 法测定血清ｓＡＰＯ－ １／Ｆａｓ。结果表明， ＨＤ 腺体内淋巴细胞Ｆａｓ－ Ｌ的表达显著高于ＧＤ 组和对照组， Ｐ＜ ０ ．００１ ；血清ｓＡＰＯ－ １／Ｆａｓ 水平，ＨＤ低于ＧＤ、对照组和正常组，Ｐ＞ ０ ．０５ 。上述结果提示，ＨＤ腺体内淋巴细胞Ｆａｓ－ Ｌ表达的观察， 有助于评估ＨＤ治疗方法， 对治疗结果的影响，并对ＨＤ的发展和预后进行判断。更多还原

【Abstract】 The article is to investigate Fas-L expression of the glandular lymphocyte and the serum levels of sAPO-1/Fas in autoimmunity thyroidits in order to find the relations between pathogenic factor and clinical value of HD. The streptavidin-peroxidase conjugated method was used to observe lymphocye Fas-L expression of thyroid cytological smears and the ELISA was used to determine levels of serum sAPO-1/Fas. The results shoued that Fas-L expression of glandular lymphocyte of HD group was higher than those of GD group and control group ( P <0.001);and the levels of serum sAPO-1/Fas of HD group was lower than those of GD group; control group and normal group ( P >0.05). To obsere Fas-L expression of glandular lymphocyte of HD will help to estimate treating effects for HD, also will help to judge the development and prognosis of HD.更多还原