【摘要】 利用ＲＩＡ 法测定了应用抗癫痫药物（ＡＥＤ） 治疗的９４ 例癫痫患者血清中催乳素（ＰＲＬ） 、生长激素（ＧＨ） 水平， 以探讨ＡＥＤ对ＰＲＬ、ＧＨ分泌的影响。结果表明， 在ＰＨＴ、ＶＰＡ 单一治疗组和ＣＢＺ＋ ＶＰＡ＋ ＰＨＴ联合治疗组中， 基础ＰＲＬ水平明显低于癫痫对照组（ Ｐ＜ ０ ．０５） ，其它治疗组ＰＲＬ有减低的趋势。在所有ＡＥＤ单一和／或联合治疗组中， 基础ＧＨ 水平与癫痫对照组相比无显著性差异（Ｐ＞ ０ ．０５） ，但均明显低于正常对照组（ Ｐ＜ ０ ．０５） 。中医药治疗组患者的ＰＲＬ、ＧＨ水平与癫痫对照组和正常对照组无显著性差异（ Ｐ＞ ０ ．０５） 。结果提示， ＡＥＤ 单一和／ 或联合治疗明显影响ＰＲＬ的分泌，而ＧＨ水平的变化与ＡＥＤ 无明显的相关性，与癫痫本身有明显的相关性， 纯中医药治疗不影响ＰＲＬ和ＧＨ 的分泌。更多还原

【Abstract】 Serum prolaction (PRL) and growth hormone (GH) levels were measured by RIA in 110 epileptic patients who were treated with antiepileptic drugs (AED) to probe into effect of AED on secretions of PRL and GH. The results showed that the basal PRL levels in phenytion (PHT) and valproate (VPA) monotherapy and CBE+PHT+VPA polytherapy groups were significantly lower than those of patients of the control group( P <0.05),the basal PRL levels in other therapy groups tend to decrease. In AED monotherapy or polytherapy groups, the basal GH levels were not significantly different from than of the control group( P >0.05), but the basal GH levels were significantly lower that that of the normal control group ( P <0.05). The serum PRL and GH levels in traditional Chinese medicine treatment group were not significantly different from those of the control group ( P >0.05).The results of this investigation indicate that the effect of AED monotherapy or polytherapy on secretion of PRL was significant. The alteration of GH levels had no correlation with AED treatment, but decreased GH levels were associated with epilpsy, which appeared to be caused parlty by epilepsy perse. The traditional Chinese medicine therapy didn′t affect the secretion of PRL and GH.更多还原