【摘要】 观察中药补肾剂──“天鼓”防治庆大霉素（GM）致耳聋作用并探讨作用机理。采用脑干诱发电位（ABR）、耳蜗铺片、血清尿素氮（BUN）及肾脏组织病理切片等方法，对补肾中药防治庆大霉素所致耳聋的听功能与肾功能变化进行同步观察。结果：周庆大霉素的豚鼠ABR阈值、血清BUN明显提高（P＜0．001～0．05），内耳基底膜毛细胞数量明显减少（P＜0．001）；中药预防45天和治疗90天，ABR阈值、基底膜形态学及肾功能均较对照组显著改善。结论：庆大霉素引起肾损害的同时也损害内耳的功能，补肾剂可能是通过对肾脏的保护作用，从而改善内耳功能。更多还原

【Abstract】 Observe kidney tonic Tiangu’s function in preventing and curing deafness caused by gentamicin (GM)and explore the pathogeny. Take the methods of brainstem evoked potential (BSEP), cochlea sectioning,serum urea nitrogen (SUN) and pathological sectioning in kidney, and observe the listening ability as well as the changes in kidney function from kidney tonic’s prevention and cure the deafness caused by GM, the result shows guinea pig’s, fed with GM, BSEP.threshold value and SUN are obviously higher (P＜0. 001～0. 05); the number of basement membrane hairy cells in inner ear are reduced a lot (P＜0. 001); prevented for 45 .days and cured for 90 days with TCD, BSER threshold value, the morphology of basement membrane and kidney function are greatly improved compared with control group. Conclusion: GM can harm the kidney as well as inner ear’s function, maybe kidney tonic improves inner ear’s function through protecting the kidney.更多还原