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人疱疹病毒8型KS330基因片段的检出与Kaposi肉瘤的关系

RELATIONSHIP BETWEEN HHV-8 KS330 GENE FRAGMENT AND KAPOSI’S SARCOMA

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【作者】 陈国敏; 曾毅;

【Author】 Chen Guomin Zeng Yi (Institute of Virology, Chinese Academy of Preventive Medicine, Beijing 100052)

【机构】 中国预防医学科学院病毒学研究所!北京100052;

【Abstract】 HHV-8 sequences were recently identified in 100% of the amplifiable samples from AIDS patients with Kaposi’s sarcoma(KS)and in 15% of the non-KS tissue samples from AIDS patients, so there is a strong correlation of Kaposi’s sarcoma with HHV-8. Serum and DNA samples from a clinically diagnosed Kaposi’s sarcoma Chinese patient were tested. HHV-8 antibody was tested positive by IFA and HIV-I antibody was negative by Western blot. The KS330 PCR product was found both in peripheral blood mononuclear cells and in KS tumor cells from this Chinese patient. This supports the hypothesis that Kaposi’s sarcoma results from infection of HHV-8.

  • 【文献出处】 病毒学报 ,CHINESE JOURNAL OF VIROLOGY , 编辑部邮箱 ,1999年03期
  • 【分类号】R373
  • 【被引频次】1
  • 【下载频次】51
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