【摘要】 目的：观察维生素 Ｄ（ Ｖｉｔ Ｄ） 突击疗法对 Ｖｉｔ Ｄ 缺乏性佝偻病的作用效果。方法：用 Ｗｉｓｔａｒ 大鼠建立幼鼠佝偻病模型并采用４ 个等级剂量的 Ｖｉｔ Ｄ３（１５ 万 Ｉ Ｕ，３０ 万 Ｉ Ｕ，６０ 万 Ｉ Ｕ，１２０ 万 Ｉ Ｕ） 分别一次性肌肉注射，并与正常对照组和模型组比较，观察幼鼠身长、体重、血钙、血磷、骨 Ｘ 片以及骨、肾、大血管病理切片。结果：治疗各组的体格、血生化、骨 Ｘ 片及骨病理学改变均恢复到正常对照组水平，经统计学处理，各实验组差异均无显著性，各组肾、腹主动脉均未见钙化灶。结论：大剂量 Ｖｉｔ Ｄ可用于佝偻病治疗。更多还原

【Abstract】 Objective:To observe the effect of a single large dose of vitamin D in treatment of rickets rats.Methods:Rickets wister rats models were experimentally established,were then divided into 4 groups.A single dose of vitamin D was injected intramus cularly in 1.5×10 5 IU,3.0×10 5 IU,6.0×10 5 IU and 12.0×10 5 IU respectively into each experimental group and the changes in rats of experimental groups were compared with those of normal contral group.Results:The rats weight,length,plasma levels of Ca 2+ ,PO 3+ 4,AKP activity,changes in X ray film and histological sections of abdominal aorta all retured to normal,with no statistical significances among different treated groups.No pathological calcification lesion was found in kidney tissues and abdominal aorta of the experimental groups.Conclusions:All 4 different single large dosages were safe and effective for curing rickets rats.更多还原