【摘要】 目的：探讨丙型病毒性肝炎（ 丙肝） 患者的细胞免疫水平及其在丙肝发病机理中的作用。方法：用生物素链霉亲和素法对１１２ 例抗 Ｈ Ｃ Ｖ 阳性患者外周血单个核细胞进行 Ｔ 细胞亚群及植物血凝素（ Ｐ Ｈ Ａ） 诱导前后ｍ Ｉ Ｌ２ Ｒ 的检测。结果：急慢性丙肝患者与正常对照相比，外周血 Ｃ Ｄ３ ＋ 、 Ｃ Ｄ４ ＋ 百分率降低， Ｃ Ｄ８ ＋ 百分率增高， Ｃ Ｄ４ ＋ ／ Ｃ Ｄ８ ＋ 比值下降（ Ｐ＜ ０ ．０５ ～ Ｐ＜ ０ ．０１） 。外周血单个核细胞在静息状态和在 Ｐ Ｈ Ａ 诱导状态，其ｍ Ｉ Ｌ２ Ｒ 表达水平与正常对照组相比均低下（ Ｐ＜ ０ ．０１） ，但急慢性丙肝患者中 Ｔ 细胞亚群及ｍ Ｉ Ｌ２ Ｒ 表达水平类似（ Ｐ＞ ０ ．０５） 。结论：丙肝患者体内存在明显的细胞免疫功能紊乱， Ｔ 细胞活化障碍，并与肝病的慢性化有关。更多还原

【Abstract】 Objective:To study the cellular immunity level and its role in the pathogenesis of hepatitis C.Methods:T cells subsets and the level of membrance interleukin 2 receptor(mIL 2R) in peripheral blood mononuclear cells(PBMC) were detected with biotin streptavidin techinque before and after PHA induction in 112 cases of hepatitis C with positive anti HCV.Results:In acute and chronic hepatitis C with positive anti HCV the levels of CD3 +、CD4 +、CD4 +/CD8 + were lower and CD8 + was higher than those in normal controls( P < 0.01 ).The expression of mIL 2R before and after PHA induction were all lower in hepatitis C than those in normal controls( P <0.01).But the level of T cells subsets and mIL 2R showed no significant difference between acute and chronic hepatitis C( P >0.05).Conclusions:The function of cellular immunity and activation of T cells are obviously in disorder in patients with hepatitis C,and that is closely associated with changing of the hepatitis into chronic.更多还原