【摘要】 目的：探讨自然杀伤（ Ｎ Ｋ） 细胞活性及过氧化脂质（ Ｌ Ｐ Ｏ） 在病毒性心肌炎发病中的作用及其相关性。方法：采用１２５ Ｉｄｕ Ｒ释放法及 Ｍ Ｄ Ａ Ｔ Ｂ Ａ 比色法，分别测定２３ 只柯萨奇（ Ｃｏｘｓａｃｋｉｅ） Ｂ３ 病毒接种 Ｂ Ａ Ｌ Ｂ／ｃ 小鼠（ 模型组） 和１０ 只健康小鼠（ 对照组）脾脏的 Ｎ Ｋ 细胞活性及心脏组织中的 Ｌ Ｐ Ｏ 含量。结果：模型组小鼠的 Ｎ Ｋ 细胞活性明显低于对照组（ Ｐ＜ ０ ．００１） ，而 Ｌ Ｐ Ｏ 明显高于对照组（ Ｐ＜ ０ ．００５） 。两者呈显著负相关（ Ｐ＜ ０ ．０１） 。结论：心肌炎小鼠存在免疫功能紊乱及 Ｌ Ｐ Ｏ 异常，氧自由基损伤是导致 Ｎ Ｋ 细胞活性下降的可能原因之一。更多还原

【Abstract】 Objective:To explore the correlation between natural killer(NK) cell activity and lipid peroxide(LPO) level in 24 weeks BALB/c mice infected with coxsackie B\-3 virus.Methods:NK cell activity and LPO level were measured by 125 IUDR and MDA TBA colorimetry in 23 experimentally infected mice and 10 normal mice.Results:NK cell activity was significantly lower( P <0.001) and LPO level was significantly higher( P <0.005) in infected mice than in normal mice. NK cell activity and LPO level were negatively correlated( P <0.01).Conclusions:Myocarditis leads to disorder in immune function in mice. LPO level is negatively correlated with NK cell activity.The decrease in NK cell activity may be due to the increase in production of oxidative free radical(OFR).更多还原