【摘要】 目的：了解３０ 岁以下宫颈癌的发病趋势、临床表现及预后。方法：对５７ 例３０ 岁以下宫颈癌患者的临床资料进行回顾性分析（ 研究组） ，并随机以同期５０ ～５５ 岁宫颈癌９６６ 例作对照研究（ 对照组） 。结果：本院３０ 岁以下宫颈癌新病例登记率，八十年代前为０－２ ％ （１０／４８１８） ，八十年代为１－２ ％ （８／６８３） ；九十年代为５－４ ％ （３９／７２０）（ Ｐ＜０－００１） 。研究组以接触性阴道流血为主要症状，占５６－１ ％ （３２／５７） 。对照组仅１６ ％ （１５６／９６６）（ Ｐ＜ ０－０１） ；ＨＰＶ 阳性率研究组为４５－９ ％ （１７／３７） ，对照组为１８－５ ％ （２２／１１９）（ Ｐ＜ ０－０１） 。盆淋巴转移率Ⅰ期两组分别为３３－３ ％ （５／１５） 及１１－３ ％ （３６／３２０）（ Ｐ＜ ０－０５） ；Ⅱ期分别为４６－２％ （１２／２６） 及２１－７％ （８８／４０６）（ Ｐ＜ ０－０１） 。５ 年生存率研究组０ 期、Ⅰ期、Ⅱ期、Ⅲ期依次为１００％ 、７２－９ ％ 、４３－７ ％ 和０，对照组依次为１００％ 、８４－２ ％ 、８２－７ ％ 和６５－２％ ，两组对照Ⅰ期无统计学意义，Ⅱ、Ⅲ期差异显著（ Ｐ＝ ０－０２７ ，Ｐ＝ ０－００１） ?更多还原

【Abstract】 Objective:To investigate the clinical characteristics and prognostic factors of the young patients with cervical carcinoma. Methods:The clinical data of 57 patients younger than 30 years (studied group) was studied retrospectively and was compared to 966 patients with CC from 50 to 55 years in control group diagnosed at the same period. Results:The percentage of young patients with CC was 1 2%(8/683) and 5 4%(39/720) in 1980s and 1990s respectively in our hospital (P< 0 001).HPV positive rate was 45 9%(17/37) and 18 5%(22/119) in studied group and control group respectively (P< 0 01). Positive rates of pelvic lymphadenometastases were 33 3%(5/15) and 11 3%(36/320)(P< 0 05) for stage 1,46 2%(12/26) and 21 7%(88/406) for stage II(P< 0 01) respetively. The 5 year survival rates of stage O,Ⅰ,Ⅱand Ⅲwas 100%,72 9%, 43 7%and 0%as well as 100%,84%,82 7%and 65 2%for studied group and control group respectively. There was no statistical difference between the two groups in stage Ⅰ.But there were statistical significant defferences in stage Ⅱ(P=0 027) and stage Ⅲ(P=0 001) between the two groups. Conclusions:①The percentage for young patients with CC has been increased in our hospital and HPV infection may be the main cause.②At the same time, young patients manifested cancerous erosion more frequently and should be differentiated from cervical erosion. ③In comparison to the control group, the prognosis of young patents was poor, it was related to higher percentage of adenocarcinoma and pelvic lymph node metastasis.更多还原