【摘要】 目的：采用不同的全身照射（TBI）剂量及分割照射方式．观察大鼠TBI后的近期效应，以选择较佳TBI方案。材料与方法：将雄性SD大鼠36只随机分对照组（4只）．7．5Gy单次照射组，8Gy单次照射组，4Gy／次X2分次照射组，5Gy／次x2分次照射组（各8只）。采用60Cor线TBI，剂量率0．9Gy／min，TBI后观察外周血像及肝肾功能的变化，井将其心，肺、肝、肾及胸椎骨髓作病理组织学检查．结果：外用血白细胞数在TBI后第3天即明显下降（86．2%），而血小板仅下降3569%：至第7天才明显下降。肝肾功能基本正常。本实验观察到，随着剂量的增加，对心、肺、肝和骨髓的损伤亦随之增加。分次照射与单次照射比较，对肺的损伤较轻，而对骨髓的损伤则略重。结论：7．5Gy单次照射可作为骨髓成功植活的最低剂量参考，分次照射对肺的损伤较小．而对骨髓的损伤则大于单次照射。关键词：##4全身照射;剂量;照射方式;近期效应;大鼠更多还原

【Abstract】 Purpose: To select the better plan for TBI. by foe observation of short－term effect of the rats by total body irradiation different TBI doses and ways of fractional irradiation. Method: of the thirty－six male SD rats 4 were placed at random in the control group. and the test are placed eqllally in the following four groups (8 in each group): 7. 5 Gy single TBI. 8 by single TBI. 4 by/per time x 2 TBI. 5 Gy/per time x 2 TBI,.60CO γ－rays being used. with the dose rate of 0. 9 Gy/min. After TBI the changes of the peripheric blood picture and the funetion of the liver and the kidney were observed and the pathology examinations of the heart. the lung the liver. the kidney and the thoractic vertebra bone marrow were carried out. Result: The ABC drops considerably (86. 2% ) three days after TBI, while PLT only drops to 35. 69%, and the nadir was on the 7th day. The flint.tion of the liver and the kidney is hasically normal. It can be seen from the test the higher the dose. the severer the injury to the heart, the lung. the liver and the bone marrow. The fractional irradiation injures the lung less severely. but it injures the bone marsow more severely than single TBI. Conclusion: 7. 5 Gy single TBI can be used as the smallest dose for the bone marrow trallsplant. Fractional irradiatiation injures the lung more slightly, but it injures the marrow more severely than single TBI.更多还原