【摘要】 建立大鼠脑缺血１ｈ后所致胃粘膜损伤模型，通过测定大鼠脑组织血流量、胃粘膜血流量、胃粘膜损伤指数，血液、胃粘膜和脑组织中一氧化氮含量，研究电针对大鼠脑缺血后胃粘膜损伤的保护作用。结果表明，电针对脑缺血所致胃粘膜损伤有保护作用。一氧化氮的前体Ｌ精氨酸预处理对胃粘膜也有保护作用，而一氧化氮合酶抑制剂Ｌ亚硝基左旋精氨酸却对胃粘膜无保护作用。结论：电针对脑缺血所致胃粘膜损伤的保护作用可能是通过激活Ｌａｒｇ－ＮＯ通路实现的更多还原

【Abstract】 Acute model of gastric mucosal damage induced by brain ischemia in rat was established.Cerebral blood flow(r CBF),gastric mucosal blood flow(GMBF),gastric mucosal lesion index(LI),the contents of nitric oxide(NO)in blood,gastric mucosal and cortex tissue were detected.The protective effect of electroacupuncture(EA) on the gastric mucosal damage during cerebral ischemia were studied.The results were follows:EA may show the protective effect on the gastric mucosal damage induced by brain ischemia after 1h in rat.By pretreatment with the precursor of NO-L arginine(L arg)may also show the gastric protective effect of EA,but by pretreatment with NO synthesis inhibitor N ω nitro L arginine(L NNA)could not show the gastric protective effect of EA in rat.It is suggested that the protective effect of EA on the gastric mucosal damage induced by brain ischemia in rat was mediated through activation of L arg-NO pathway.更多还原