【作者】 李青； 万芝力； 杨晓泉；

【Author】 Li Qing;Wan Zhili;Yang Xiaoquan;School of Food Science and Engineering,South China University of Technology;School of Food Science and Engineering,Central South University of Forestry and Technology;

【机构】 食物蛋白与胶体研究中心华南理工大学食品科学与工程学院； 中南林业科技大学食品科学与工程学院；

【摘要】 无机金属纳米材料与生物活性凝胶因子的有机结合,成为构建多功能水凝胶的有效策略。基于此,本研究利用天然活性小分子甘草酸(GA)在水溶液中的自组装特性及其与二维纳米材料MXene的协同还原作用,结合甲基丙烯酸酐化明胶(GMA)光交联特性,构建了一种新型GA基杂化功能性水凝胶(GN-GMA-MAg-DN水凝胶)。研究结果表明,GN-GMA-MAg-DN水凝胶具有典型的互穿型双网络结构,表现出优异的力学性能、高皮肤黏附性和自修复能力。特别地,该水凝胶展现出显著的光热转换性能(光热转换效率为32.4%)及活性控释特性:水凝胶在近红外光作用下升高温度的同时,可实现凝胶-弱凝胶的转变,进而促进凝胶基质内抗菌物质的可控性释放,最终赋予水凝胶更优异的光热协同抗菌(对MRSA和E.coli的抗菌率分别达到98.88%和99.99%)及抗生物被膜的能力。本研究结果为新型天然产物活性小分子基光热水凝胶的制备及其在抗菌领域的应用提供了新思路。更多还原

【Abstract】 Combining inorganic metal nanomaterials with organic substances(e.g.,bioactive small molecules) possessing inherent biological activities is emerging as a highly effective and promising strategy to endow hydrogels with considerable multifunctional effects.In this study,a novel glycyrrhizic acid(GA)-based hybrid photothermal hydrogel(i.e.,GN-GMAMAg-DN hydrogel) was fabricated by combining the self-assembly behavior of GA in aqueous solution and its synergistic reduction effect with two-dimensional MXene nanosheets,as well as the photo-crosslinking ability of methacrylate-modified gelatin(GMA).The resulting hydrogel exhibits a typical interpenetrating double-network structure,which endows the hydroogel with excellent mechanical properties,high skin adhesiveness,and self-healing capability.Under near-infrared(NIR) light irradiation,the hydrogel demonstrates remarkable photothermal conversion performance.Notably,the photothermally induced temperature increase triggers a transition from a hydrogel to weaken hydrogel,thereby facilitating the controlled release of antimicrobial agents and endowing the resulting hydrogels with superior antibacterial and anti-biofilm activities.This work provides a novel pathway for creating the multifunctional nanocomposite hydrogels from natural drug-food homologous molecules and highlights their roles in efficient antibacterial therapy.更多还原