【作者】 王煚楠； 翟池； 尹诗语； 冯志远； 夏嘉跃； 孙桂菊；

【Author】 Wang Jiongnan;Zhai Chi;Yin Shiyu;Feng Zhiyuan;Xia Jiayue;Sun Guiju;Key Laboratory of Environmental Medicine and Engineering of Ministry of Education/Department of Nutrition and Food Hygiene, School of Public Health, Southeast University;

【机构】 环境医学与工程教育部重点实验室/公共卫生学院营养与食品卫生系,公共卫生学院,东南大学；

【摘要】 目的以骨骼肌质量(SMM)和功能进行性丧失为特征的肌少肉减少症(简称肌少症)是60岁以上老年人的主要健康问题。了解脂肪、SMM和肌少症风险之间的关系对其预防和管理至关重要。方法本次横断面研究纳入人群为2024年4月至12月在江苏省如皋市和东台市参与老年人健康检查项目的 1523名60岁及以上老年人。采用生物电阻抗分析法(BIA)测量身体成分参数,如脂肪量(FM)和SMM。参与者根据不同的年龄范围分为三组:60至70岁组、71至80岁组和80岁以上组。结果 1523名参与者中,60至70岁年龄组有633人,71至80岁年龄组有747人,80岁以上有143人。三个年龄组的肌少症患病率分别为7.42%、13.39%和46.15%。多因素logistic回归结果显示,年龄、性别、身体质量指数(BMI)、左小腿围、FM和体脂百分比与肌少症显著相关。标准logistic回归模型结果显示,年龄与肌少症风险显著正相关(OR:1.15,95%CI:1.12-1.18,P <0.001),BMI (OR:0.70,95%CI:0.66-0.74,P <0.001)和FM (OR:0.91,95%CI:0.89-0.94,P <0.001)均与肌少症风险显著负相关。分段线性回归分析结果表明,当年龄超过79.90岁时,年龄与身体质量指数呈显著负相关(β:-0.368,95%CI:-0.56-0.18,P <0.001)。当年龄超过73.43岁时,其与FM呈显著负相关(β:-0.347,95%CI:-0.50--0.20,P <0.001)。年龄在80.00岁以上时,其与体脂百分比呈显著负相关(β:-0.486,95%CI:-0.91--0.06,P=0.025)。在低于82.00的年龄范围内,其与四肢骨骼肌质量显著负相关(β:-0.109,95%CI:-0.15-0.06,P <0.001)。结论在60岁及以上的老年人中,年龄、身体质量指数、体质量、体脂百分比和小腿围都是肌肉减少症的独立影响因素。检测老年人的身体成分对于肌少症的早期识别和干预至关重要。更多还原

【Abstract】 Objective Sarcopenia, characterized by progressive loss of skeletal muscle mass(SMM) and function,is a major health issue among the elderly over 60 years old. Understanding the relationship between fat, SMM and the risk of sarcopenia is crucial for its prevention and management. Methods This cross-sectional study included 1,523 elderly individuals aged 60 and above who participated in the elderly health check-up project in Rugao City and Dongtai City, Jiangsu Province from April to December 2024. Body composition parameters such as fat mass(FM) and SMM were measured using bioelectrical impedance analysis(BIA). Participants were divided into three groups based on different age ranges: the 60-70 years old group, the 71-80 years old group, and the over 80 years old group. Results Among the 1,523 participants, there were 633 individuals aged 60 to 70, 747 aged 71 to 80, and 143 over 80. The prevalence rates of sarcopenia in the three age groups were 7.42%, 13.39%, and 46.15%,respectively. The results of multivariate logistic regression showed that age, gender, body mass index(BMI), left calf circumference, FM, and body fat percentage were significantly associated with sarcopenia. The results of the standard logistic regression model indicated that age was significantly positively correlated with the risk of sarcopenia(OR: 1.15, 95% CI: 1.12-1.18, P < 0.001), while BMI(OR: 0.70, 95% CI: 0.66-0.74, P < 0.001) and FM(OR: 0.91, 95% CI: 0.89-0.94, P < 0.001) were significantly negatively correlated with the risk of sarcopenia.The piecewise linear regression analysis results showed that when age exceeded 79.90 years, age was significantly negatively correlated with BMI(β:-0.368, 95% CI:-0.56--0.18, P < 0.001). When age exceeded 73.43 years, it was significantly negatively correlated with FM(β:-0.347, 95% CI:-0.50--0.20, P < 0.001). When age was over 80.00 years, it was significantly negatively correlated with body fat percentage(β:-0.486, 95% CI:-0.91--0.06, P = 0.025). Within the age range below 82.00 years, age was significantly negatively correlated with appendicular skeletal muscle mass(β:-0.109, 95% CI:-0.15--0.06, P < 0.001). Conclusions Among people aged 60 and above,age, body mass index, body weight, body fat percentage and calf circumference are all independent influencing factors of sarcopenia. Detecting the body composition of the elderly is crucial for the early identification and intervention of sarcopenia.更多还原