【作者】 覃丽媛； 衣喆； 张玉梅； 薛勇；

【Author】 Qin Liyuan;Yi Zhe;Zhang Yumei;Xue Yong;College of Food Science and Nutritional Engineering,China Agricultural University;Fastco Biotech (Hangzhou) Co.,Ltd.;Peking University School of Public Health,Peking University;

【机构】 中国农业大学食品科学与营养工程学院； 脂代生物科技(杭州)有限公司； 北京大学医学部公共卫生学院；

【摘要】 非酒精性脂肪肝病(NAFLD)已成为全球性的健康挑战,与肥胖和代谢紊乱紧密相关,脂质积累和脂代谢紊乱是关键特征。甘油二酯(DAG)作为油脂中的天然成分,具有与甘油三酯(TAG)不同的代谢特性,可能有助于控制体重和减少脂质积累。本研究目的在于探究DAG在改善NAFLD过程中对脂质堆积和脂代谢的影响。采用了随机、双盲、对照的临床试验设计,招募BMI在22至30 kg/m2之间的成年男女,并随机分配到DAG或TAG组进行为期八周的饮食干预。在干预的各个阶段,对受试者的体格、血液生理生化以及临床指标进行了测量。研究发现,与TAG组相比,DAG组在第八周时血清甘油三酯、小而密低密度脂蛋白和尿酸等指标与基线的变化具有显著性;此外,DAG组干预后的血清总胆固醇、总体脂率和内脏脂肪面积等指标相对于基线显著减少,且未发现不良反应。因此,甘油二酯油替代甘油三酯油作为膳食脂肪来源,可能有助于维持血脂平衡,减少体脂肪和肝脏中甘油三酯的积累,从而降低非酒精性脂肪肝病的发病风险。更多还原

【Abstract】 Non-alcoholic fatty liver disease(NAFLD),a global health concern,is associated with obesity and metabolic disorders,featuring lipid accumulation and metabolic disturbances.Diacylglycerol(DAG),a natural component,exhibits unique metabolic properties distinct from triacylglycerol(TAG),which may aid in weight loss and reduce lipid accumulation.This study investigates the effects of DAG on lipid accumulation and metabolism in NAFLD treatment.A randomized,doubleblind,controlled clinical trial was conducted with adults(BMI 22-30 kg/m2) randomly assigned to DAG or TAG dietary intervention groups for 8 weeks.Physical,blood biochemical,and clinical parameters were assessed throughout the intervention.The results showed that the DAG group had a significant reduction in serum triacylglycerol,small dense low-density lipoprotein,and uric acid levels by the eighth week compared to the TAG group.Additionally,the DAG group demonstrated a notable decrease in serum total cholesterol,total body fat and visceral fat area post-intervention,with no adverse effects reported.Thus,replacing triacylglycerol oil with diacylglycerol oil as a dietary fat source may promote lipid balance,reduce body fat,and decrease liver triacylglycerol accumulation,potentially lowering the risk of NAFLD.更多还原