【作者】 侯永青； 夏海硕； 何天宝； 张博华； 邱桂平； 陈安涛；

【Author】 Yongqing Hou;Haishuo Xia;Tianbao He;Bohua Zhang;Guiping Qiu;Antao Chen;Key Laboratory of Cognition and Personality of Ministry of Education, Faculty of Psychology,Southwest University;Clinical Laboratory of Psychiatry, Mental Health Center of Guangyuan;College of Education, Psychology and Social Work,Flinders University;College of Education, Ningxia University;School of Psychology, Shanghai University of Sport;

【机构】 西南大学心理学部； 广元市精神卫生中心； 澳大利亚阿德莱德弗林德斯大学教育,心理与社会工作学院； 宁夏大学教师教育学院； 上海体育大学心理学院；

【摘要】 精神病风险综合征(psychosis risk syndrome,PRS)早于精神病出现,评估精神病高风险个体的神经心理异常有助于精神病的早期识别和早期积极干预。本研究的目标是讨论在有干扰刺激时,PRS个体的N200和P300反应是否存在缺损并与其临床结果有关。共有223名参与者,包括122名符合PRS标准的个体,50名情绪障碍个体(emotional disorder,ED)和51名健康对照个体(healthy controls,HC)。使用由不同颜色的正方形图片组成的有干扰刺激的三刺激视觉Oddball范式,采集所有参与者的EEG数据。对几乎所有的PRS个体随访追踪12个月并将其重新分成了三个组别:PRS-conversion,PRS-symptomatic,and PRS-remission,比较临床结果各组在基线N200和P300反应上的差异。PRS组的平均N200波幅显著大于HC组(p=0.002,d=0.53);ED组的平均N200波幅介于HC和PRS之间,但与HC和PRS的差异均未达到统计学意义(p=0.15,d=0.27;p=0.17,d=0.22)。在随访12个月后的临床结果各组上,PRS-conversion组的基线平均N200波幅显著大于PRS-symptomatic组(p=0.043,d=0.58)和PRS-remission组(p=0.046,d=0.50),也显著大于HC组(p <0.001,d=0.97)。PRS-symptomatic组和PRS-remission组的基线平均N200波幅均显著大于HC组(p=0.023,d=0.46;p=0.044,d=0.38),但PRS-symptomatic组和PRS-remission组之间无显著差异(p=0.93,d=0.02)。在P300反应上未发现任何有统计学意义的结果 (ps> 0.05)。本研究发现PRS及转化为精神病的PRS个体在有干扰刺激的注意加工中存在明显的N200波幅缺损,N200波幅具有作为PRS临床结果预后生物标志物的潜力。更多还原

【Abstract】 Schizophrenia often occurs in youth, and psychosis risk syndrome(PRS) occurs before the onset of psychosis. The present study aimed to determine whether the visual event-related potential responses in youth with PRS were defective in the presence of interference stimuli and associated with their clinical outcomes. In total, 223participants, including 122 patients with PRS, 50 patients with emotional disorders(EDs), and 51 healthy controls(HCs) were assessed. Baseline electroencephalography was recorded during the three-stimulus visual Oddball task.The event-related potentials induced by square pictures with different colors were measured. Almost all patients with PRS were followed up with for 12 months and reclassified into three groups: PRS-conversion,PRS-symptomatic, and PRS-remission. The differences in baseline event-related potential responses were compared among the clinical outcome groups. The average N2 amplitude of the PRS group was significantly less negative than that in the HC group(p = 0.002, d = 0.53). The baseline average N2 amplitude in the PRS-conversion group was significantly less negative than that in the PRS-symptomatic(p = 0.043, d = 0.58),PRS-remission(p = 0.046, d = 0.50), and HC groups(p < 0.001, d = 0.97). The average N2 amplitude did not differ between PRS-symptomatic and PRS-remission groups(p = 0.93, d = 0.02). However, it was significantly less negative in the PRS-symptomatic and PRS-remission groups than in the HC group(p = 0.023, d = 0.46; p =0.044, d = 0.38). No statistically significant results were found in the P3 response. This study found that youth with PRS had significant N2 amplitude defects in attention processing with interference stimulus. N2 amplitude shows a potential prognostic biomarker of clinical outcome in the PRS.更多还原