【作者】 华深； 喻跃国； 刘晓波； 张晨； 罗晓东；

【Author】 HUA Shen;YU Yue-Guo;LIU Xiao-Bo;ZHANG Chen;LUO Xiao-Dong;The Second Hospital of Jinhua Zhejiang;Shanghai Mental Health Center,Shanghai Jiao Tong University School of Medicine;

【机构】 浙江省金华市第二医院； 上海交通大学医学院附属精神卫生中心；

【摘要】 目的:探讨囊泡单胺转运蛋白2基因(VMAT2)多态性与糖尿病患者抑郁状态相关性。方法2017年5月～2019年2月期间本院收治的300例糖尿病患者,随机抽取50例合并抑郁的患者,设为糖尿病+抑郁组;随机抽取56例未合并抑郁的糖尿病患者,设为糖尿病组。统计糖尿病组、糖尿病+抑郁组的VMAT2基因多态性分布情况。对合并抑郁进行Logistic回归分析,筛选影响抑郁发生的独立危险因素。比较不同基因型的抑郁患者基线HAMD评分。统计并比较显效组与未显效组的基因型分布情况。结果:糖尿病+抑郁组rs363371基因位点的GG基因型比率均明显高于糖尿病组(24.00%vs8.93%),差异有统计学意义(P<0.05)。家庭人均月收入、并发症情况、rs363371 (GG基因型)为糖尿病合并抑郁的独立危险因素。rs363371 (GG基因型)患者的HAMD评分为(27.62±3.02),均明显高于AA基因型(22.17±2.29)、AG基因型(23.67±2.27),差异有统计学意义(P<0.05)。结论:VMAT2上的rs363371 (GG基因型)增加了糖尿病人群发生抑郁的风险,也是糖尿病患者伴发抑郁的危险因素。更多还原

【Abstract】 Objective To explore the correlation between the polymorphism of VMAT2 gene and depression in diabetic patients.Methods From May 2017 to February 2019,50 patients with diabetes who were admitted to our hospital were randomly selected and assigned to the diabetes+depression group.56 diabetic patients without depression were randomly selected as the diabetes group.The polymorphism distribution of VMAT2 gene in diabetes group and diabetes +depression group was calculated.Logistic regression analysis was performed for combined depression,and independent risk factors affecting the occurrence of depression were screened.Baseline HAMD scores of depressed patients with different genotypes were compared.The genotype distribution of the active group and the non-active group was calculated and compared.Results The GG genotypes of rs363371 in the diabetes+depression group were significantly higher than those in the diabetes group(24.00%vs 8.93%),with statistically significant differences(P<0.05).Family per capita monthly income,complications,rs363371(GG genotype) were independent risk factors for diabetes combined with depression.The HAMD scores of rs363371(GG genotype) patients were(27.62±3.02),which were significantly higher than AAgenotypes(22.17±2.29) and AG genotypes(23.67±2.27)(P<0.05).Conclusion rs363371(GG genotype) on VMAT2 increase the risk of depression in diabetics and are also increase the risk for depression in diabetics.更多还原