【作者】 沈宵； 胡洁茹； 曾芬； 田伟强； 骆松梅；

【机构】 浙江中医药大学； 丽水市中心医院药学部；

【摘要】 目的 :对两种术后镇痛方案进行药物经济学评价,为临床合理用药提供指导。方法 :回顾性分析胸外科开胸术后患者使用静脉自控镇痛泵(patient controlled intravenous analgesia,PCIA)治疗的情况,87例病例根据镇痛泵内药物分为A组(地佐辛+右美托咪定+托烷司琼)和B组(地佐辛+布托啡诺+托烷司琼),用药两天后观察镇痛疗效和不良反应,并运用药物经济学成本-效果法分析两组治疗方案。结果 :A、B组疼痛缓解率分别为97.78%、97.62%,两组无显著性差别(P>0.05)。各组均无严重不良反应出现,不良反应发生率分别为13.33%、4.76%,无显著性差别(P>0.05)。A、B组人均成本分别为1473.06,1110.61,成本-效果比分别为15.07,11.38。结论:手术48h后,两组方案疼痛缓解率无显著性差异,B组花费较低,且不良反应发生比例也较低。更多还原

【Abstract】 OBJECTIVE To explore the cost-effectiveness of two analgesic regimens for analgesia after thoracic surgery,and then to provide guidance for rational drug use in clinical practice.METHODS The paper would observe 87 patients who were treated with patient-controlled intravenous analgesia(PCIA) and divided into Group A(desozin + dexmedetomidine + tropisetron) and Group B(desozin +butorphanol + tropisetron) in light of the medication in the analgesic pump to find out their reactions after taking 2-day analgesic treatment and to conduct a pharmacoeconomic analysis of the cost-effectiveness of the two treatment options.RESULTS As is shown in the results, the pain relief rates of Group A and Group B were 97.78% and 97.62%respectively, and there was no significant difference between the two groups(P>0.05). The rates of adverse reactions in Group A and Group B were 13.33% and 4.76% respectively, mainly represented by hypotension, nausea and vomiting. The costs per capita in Group A and Group B were 1473.06 and 1110.61 respectively, and the costeffectiveness ratios were 12.46 and 10.44 respectively.CONCLUSION Based on these findings, it could be concluded that there was no significant difference in pain relief rate between the two groups within 48 hours after surgery and Group B cost less money and witnessed fewer adverse reactions.更多还原