Downregulation of microRNA-222 facilitates endothelial progenitor cell function in patients with coronary artery disease through targeting STAT5A

【作者】 许文峰； 张浩； 凌锐； 孙文文； 任国庆；

【机构】 江苏大学附属医院；

【摘要】 <正>Results:miR-222 was significantly higher in CAD EPCs than in healthy donor-derived EPCs. Overexpression of miR-222 in healthy donor-derived EPCs contributed to decreases in proliferation, adhesion, and migration in vitro. Conversely, downregulation of miR-222 effectively reverted CAD EPC functions. STAT5 A is a target of miR-222 in EPCs. The overexpression or inhibitory level of miR-222 regulated VEGF production and p38 mitogen-activated protein kinase(MAPK) activation in human EPCs.更多还原