【作者】 刘扬； 李世宏； 陈莉莉； 蔡凤珠； 张懿行； 姜月； 徐硕； 曹红； 肖绍坦；

【Author】 LIU Yang;Li Shi-hong;CHEN Li-li;CAI Feng-zhu;ZHANG Yi-xing;JIANG Yue;XU Shuo-hua;CAO Hong;XIAO Shaotan;Pudong New Area Center for Disease Control and Prevention;

【机构】 Pudong New Area Center for Disease Control and Prevention；

【摘要】 目的分析耐药结核病的研究现状,为今后耐药结核病相关研究提供参考。方法于2021年6月10日,以Web of Science核心合集数据库为数据源,以TS=("tuberculosis" AND "resistant")为检索式,对2011—2020年间发表的关于耐药结核病的文献进行检索,共纳入符合标准的文献9479篇。采用文献计量学研究和可视化分析工具对全球耐药结核病研究的年代、国家、学科类别和关键词等进行分析。结果近10年耐药结核病相关研究的文献数量居于较高水平且呈逐年升高趋势(r=0.96,P<0.05);美国是发文量最多的国家(28.22%,2675/9479)且h指数高达107,我国居于第三位(12.67%,1201/9479);发文机构主要隶属于美国、南非和英国,我国首都医科大学位列第六;发文量最多的学科类别为传染性疾病(Infectious Diseases),共2416篇(25.49%);"利福平"、"异烟肼"、"HIV"、"药敏试验"、"细胞毒性"等为耐药结核病文献中出现频率较高的关键词。结论耐药结核病相关研究呈良好发展态势,我国应顺应时势继续加大耐药结核病的研究力度,不断提高耐药结核病防治的科学水平。更多还原

【Abstract】 Objective To analyze the research status of drug-resistant tuberculosis and provide references for future research.Methods Papers on drug-resistant tuberculosis published from 2011 to 2020 were retrieved in Web of Science core collection database.The retrieval strategies were set as follows:TS=( "tuberculosis" AND "resistant").The survey included standards-compliant 9479 articles.By bibliometric and visualizer,the research status of drug-resistant tuberculosis was revealed from the aspects of time,country,discipline and key words.Results Output of literatures on drug-resistant tuberculosis had been at a high level and yearly output of articles had been increasing(r=0.96,P <0.05).The United States had the greatest number of articles with 2675 accounting for 28.22 percent of the total and had the highest h-index of 69.Our country ranked third with 1201 articles accounting for12.67 percent of the total.Main productive institutions were affiliated to the United States,South Africa and the Britain,while Capital Medical University in our country ranked sixth.The most studied subject was Infectious Diseases with 2416 articles accounting for 25.49 percent of the total. "Rifampicin", "isoniazid", "HIV", "drug susceptibility testing" and "cytotoxicity" were high frequency keywords that had appeared.Conclusion Related studies on drug-resistant tuberculosis show a good development trend.Our country should continue to do more research complying with the tendency to improve the scientific level of prevention and control for drug-resistant tuberculosis.更多还原