【作者】 牛晓艳； 任克良； 曹亮； 李燕平； 郑建婷； 冯国亮； 詹海杰； 唐耀平； 刘文忠；

【Author】 Niu Xiao-yan;Ren Ke-liang;Cao-liang;Li yan-ping;Zheng jian-ting;Feng guo-liang;Zhan hai-jie;Tangyao-ping;Liu Wen-zhong;Sciences of ShanXi Agricultural Academy Institute of Animal Husbandry & Veterinary;College of Animal Science and Veterinary Medicine,Shanxi Agricultural University;

【机构】 山西省农业科学院畜牧兽医研究所； 山西农业大学动物科学院；

【摘要】 卵泡刺激素(FSH)刺激颗粒细胞增殖并控制卵泡的发育和成熟。在这个针对獭兔的研究中,采用白色獭兔品系的70只母兔和海狸色獭兔品系的100只母兔,我们研究了FSHβ的SNPs与繁殖性状间的关系。发现在FSHβ基因外显子1和外显子3中的3个SNPs(FSH2,FSH30,FSH31)在联合群体中与繁殖性状具有强相关。对于FSH2,与TT基因型相比,GG基因型与较高的总产仔数(TNB)和产活仔数(NBA)相关联(P <0.05)。对于FSH30,AA基因型的总产仔数(TNB)和产活仔数(NBA)比GG基因型和AG基因型显著较高(P <0.05)。对于FSH31,GG基因型比AG基因型具有较高的总产仔数(TNB),初生窝重(LWB)和21日龄活仔数(LS21)(P <0.05),比AG基因型个体具有极显著较高的产活仔数(NBA)(P <0.01)。结论是FSHβ基因与獭兔的繁殖性状相关联,因此,FSH2,FSH30和FSH31可作为分子标记对獭兔进行选育。更多还原

【Abstract】 Follicle-stimulating hormone(FSH) stimulate granulosa cell proliferation and controls the development and maturation of oocytes.In this study with Rex rabbit,there was exploration of the relationships between reproductive traits and SNPs of FSHβ,using 70 females from the White line and 100 females from the Beaver line.Three SNPs(FSH2,FSH30,FSH31) in exon1 and exon3,of FSHβ were strongly associated with reproductive traits in the combined population.For FSH2,the GG variant were associated with greater(P < 0.05) values for total number born(TNB) and number born alive(NBA),compared to those with the TT variant.For FSH 30,for the AA variant there was greater(P < 0.05) values for TNB and NBA than the GG and AG variants.For FSH31,the GG variant was associated with greater(P < 0.05) values for TNB,litter weight at birth(LWB) and litter size at 21 days of age(LS21),than the AG variant,and with the greater(P < 0.01) values for NBA than the AG variant.It is concluded that genetic variation in FSHβ gene is associated with reproductive traits in the Rex rabbit,therefore,the FSH2,FSH30 and FSH31 SNPs can be used as molecular markers in genetic selection of rabbits.更多还原