【作者】 申燕婷； 梁丽佳； 李志远； 施维； 徐蔚青； 徐抒平；

【Author】 SHEN Yan-ting;LIANG Li-jia;LI Zhi-yuan;SHI Wei;XU Wei-qing;XU Shu-ping;State Key Laboratory for Supramolecular Structure and Materials,Institute of Theoretical Chemistry,Jilin University;Key Lab for Molecular Enzymology & Engineering of Ministry of Education,Jilin University;

【机构】 吉林大学超分子结构与材料国家重点实验室理论化学研究所； 吉林大学分子酶学工程教育部重点实验室；

【摘要】 作为细胞信号传导和氧化应激压力的调控者,ROS(reactive oxygen species)在细胞及生命体的多种活动中发挥了重要作用。本研究以监测亚细胞器ROS为目的,设计了一种基于细胞器靶向的氧化还原反应的SERS纳米传感器,实现了对亚细胞层次ROS的监测,对于深入理解ROS在细胞生命活动的作用具有重要意义。更多还原

【Abstract】 As the regulator of cell signaling and oxidative stress,ROS(reactive oxygen species) plays an important role in various activities of cells and living organisms.In this study,with the purpose of monitoring the ROS in subcellular organelle,the interference-free SERS nanosensor based on the redox reaction with mitochondria targeting ability were designed and used.And the reliable monitoring of ROS at subcellular level was also realized,which is of great importance in deeply understanding the role of ROS in the therapeutic process and the treatment mechanism.更多还原