The role of SIRT4-induced oxidative stress on regulating the growth of renal clear cell carcinoma

【作者】 童颖； 郑慧； 谢素红； 王砚春； 卢仁泉； 郭林；

【机构】 复旦大学附属肿瘤医院检验科； 复旦大学肿瘤学系；

【摘要】 <正>Clear cell renal cell carcinoma is a common type of malignant kidney tumors,approximately accounting for 60%～85%in renal carcinoma.ccRCC is not sensitive to chemotherapy or radiotherapy,these therapies usually have great side-effect.Thus,it is very necessary to develop an effective therapeutic method.Sirt4 is located in mitochondria and represses the metabolism of glutamine into tricarboxylic acid cycle.更多还原