High Yield of Au Nanobipyramids as Tunable Light-Absorber for Tumor Suppression in the Second Near-Infrared Window

【作者】 Li-Feng Hang； Si-Min Lin； Hong-Dong Shi； Ping-Yu Zhang； 张黔玲；

【Author】 Li-Feng Hang;Si-Min Lin;Hong-Dong Shi;Ping-Yu Zhang;Qian-Ling Zhang;College of Chemistry and Environmental Engineering,Shenzhen University;

【机构】 College of Chemistry and Environmental Engineering,Shenzhen University； 深圳大学；

【摘要】 Gold nanobipyramids（AuNBys） with the high local electric-field enhancements,tunable longitudinal localized surface plasmon resonance（LSPR） peak,and high-Z elements are ideal candidates for tumor diagnostics and therapy in the second near-infrared（NIR-Ⅱ） windows.^[1] However,the reported strategies to synthesis AuNBys involved using Au nanoparticles（NPs） smaller than 5 nm as seeds,and the AuNBys with the low yield（<60%） should be purified by complex process for further use.^[2] Moreover,the AuNBys were prepared by using decahedra AuNPs with larger size,but possessed broad longitudinal LSPR peaks in NIR-Ⅱ windows because of inhomogeneous size of seeds.Herein,we presented a facile seed mediated method to prepare the high yield（>95%）,high extinction coefficient(2.0×10¹¹ M^-1 cm^-1),and photothermal conversion efficiency（44.2%） of AuNBys with narrow longitudinal LSPR peak in the NIR-Ⅱ windows without purification.Based on these AuNBys,we have developed multifunctional nanomaterials AuNBys,AuNBys@TiO₂ and AuNBys@Cu_xS for tumor photo-radiotherapy,photodynamic and photothermaldynamic therapy.更多还原

【Abstract】 Gold nanobipyramids（AuNBys） with the high local electric-field enhancements,tunable longitudinal localized surface plasmon resonance（LSPR） peak,and high-Z elements are ideal candidates for tumor diagnostics and therapy in the second near-infrared（NIR-Ⅱ） windows.^[1] However,the reported strategies to synthesis AuNBys involved using Au nanoparticles（NPs） smaller than 5 nm as seeds,and the AuNBys with the low yield（<60%） should be purified by complex process for further use.^[2] Moreover,the AuNBys were prepared by using decahedra AuNPs with larger size,but possessed broad longitudinal LSPR peaks in NIR-Ⅱ windows because of inhomogeneous size of seeds.Herein,we presented a facile seed mediated method to prepare the high yield（>95%）,high extinction coefficient(2.0×10¹¹ M^-1 cm^-1),and photothermal conversion efficiency（44.2%） of AuNBys with narrow longitudinal LSPR peak in the NIR-Ⅱ windows without purification.Based on these AuNBys,we have developed multifunctional nanomaterials AuNBys,AuNBys@TiO₂ and AuNBys@Cu_xS for tumor photo-radiotherapy,photodynamic and photothermaldynamic therapy.更多还原